{"id":"W2531131639","doi":"10.1038/cddiscovery.2015.19","title":"Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers","year":2015,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; York University; Heart and Stroke Foundation of Canada","keywords":"Mef2; Apoptosis; Myocyte; Cell biology; Signal transduction; Gene silencing; Biology; MEF2C; Transcription factor; Cancer research; Enhancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843319,0.0003913702,0.00055694,0.0002000165,0.0001860809,0.000276823,0.0002068043,0.0002618653,0.002064944],"category_scores_gemma":[0.0001742905,0.0001397242,0.0003281707,0.0001094073,0.0001344741,0.000161336,0.0001752675,0.0006617955,0.0004205391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001296886,"about_ca_system_score_gemma":0.0001136311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001678224,"about_ca_topic_score_gemma":0.0003374112,"domain_scores_codex":[0.9997277,0.00006299588,0.00003929315,0.00004829021,0.00005942239,0.00006223559],"domain_scores_gemma":[0.9998643,0.00003345882,0.00003061328,0.00001463699,0.00001682271,0.00004012471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002341234,0.00006217269,0.0001691201,0.00005188846,0.000008429427,0.00004294154,0.00001049467,0.00002451182,0.9980515,0.00004250683,0.00006867131,0.001233552],"study_design_scores_gemma":[0.00006119294,0.000670182,0.006324829,0.0000159011,0.00002888698,0.0002310499,0.00002495341,0.0005813551,0.988447,0.0000299343,0.003579188,0.000005554743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822462,0.008967891,0.003882643,0.0002440299,0.0001922997,0.00005865236,0.0004820187,0.0001630981,0.0037633],"genre_scores_gemma":[0.9873883,0.004474119,0.003056736,0.0001795195,0.00008849539,0.0001653211,0.0008802043,0.00005009822,0.003717214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002064944,"threshold_uncertainty_score":0.00690794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507001584345402,"score_gpt":0.2586985973027568,"score_spread":0.2336285814593028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}