{"id":"W2531131639","doi":"10.1038/cddiscovery.2015.19","title":"Pro-survival function of MEF2 in cardiomyocytes is enhanced by β-blockers","year":2015,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; York University; Heart and Stroke Foundation of Canada","keywords":"Mef2; Apoptosis; Myocyte; Cell biology; Signal transduction; Gene silencing; Biology; MEF2C; Transcription factor; Cancer research; Enhancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002273094,0.0001413904,0.0004213008,0.00008227787,0.00001768764,0.00001945464,0.00004707579,0.0001016939,0.000009595723],"category_scores_gemma":[0.00002638421,0.0001154917,0.0002010076,0.0001636035,0.0000422589,0.0001674929,0.00003970968,0.0001273833,0.00001676621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001004317,"about_ca_system_score_gemma":0.0001510371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001671053,"about_ca_topic_score_gemma":0.000002997042,"domain_scores_codex":[0.9988818,0.0000324001,0.0002768676,0.00026083,0.0003391138,0.0002090213],"domain_scores_gemma":[0.9994527,0.00002259982,0.00007426192,0.0002606208,0.00008428546,0.0001056099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001294988,0.0003969624,0.05738173,0.0005023923,0.0001774636,0.000006101726,0.001325342,0.0006488971,0.9170023,0.0001081936,0.01814809,0.00300759],"study_design_scores_gemma":[0.004885376,0.0005634004,0.0178431,0.0003708651,0.0003503835,0.000004291391,0.00190464,0.0008316935,0.9610474,0.0002466373,0.0115667,0.0003855861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787265,0.002483755,0.001676147,0.0001182725,0.0005448101,0.0002858311,0.00002405903,0.0000217201,0.0161189],"genre_scores_gemma":[0.9963824,0.0001787221,0.0002327389,0.0001010549,0.0001400572,0.00001180384,0.00004784733,0.00002291924,0.002882426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04404508,"threshold_uncertainty_score":0.4709617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02507001584345402,"score_gpt":0.2586985973027568,"score_spread":0.2336285814593028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}