{"id":"W2531259652","doi":"10.1371/journal.pgen.1006296","title":"Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Toronto General Hospital; University Health Network","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Association Anne de Bretagne Genetique; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Broad Institute; National Human Genome Research Institute; Ontario Institute for Cancer Research; Conseil Régional des Pays de la Loire; Division of Cancer Prevention, National Cancer Institute; Génome Québec; Ministerio de Economía y Competitividad; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Genome-wide association study; Colorectal cancer; Biology; Genetics; Genotype; Genetic association; Genetic predisposition; Cancer; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174878,0.0001335212,0.0002337225,0.00005510007,0.00008197037,0.000009435285,0.00006941929,0.0001669537,0.00001198988],"category_scores_gemma":[0.0003108107,0.0001072516,0.00005170187,0.00003561736,0.000111532,0.000003187633,0.00007834389,0.0000414885,7.172769e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001895255,"about_ca_system_score_gemma":0.00003252763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001912075,"about_ca_topic_score_gemma":0.00006347524,"domain_scores_codex":[0.9990063,0.0001085199,0.0003062208,0.000311466,0.0000671104,0.0002003693],"domain_scores_gemma":[0.9991874,0.0002074033,0.0002729621,0.0001402909,0.0001217169,0.00007026078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002431263,0.00001213001,0.6329588,0.00001751397,0.0002409299,7.324814e-8,0.00002485917,0.00006162495,0.3633205,6.832708e-7,0.00002106328,0.003317456],"study_design_scores_gemma":[0.0006430207,0.0002352623,0.8755859,0.00001894145,0.0003249627,0.000002078766,0.00002039383,0.0004866435,0.1220927,0.0001610221,0.0002981354,0.0001309707],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901109,0.002260298,0.006940615,0.00008199714,0.00006282694,0.000275215,0.000249285,0.000005339732,0.00001348757],"genre_scores_gemma":[0.9890802,0.007018425,0.00359625,0.00003159421,0.0001352063,0.00005439874,0.00003757995,0.00001884803,0.00002747956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.242627,"threshold_uncertainty_score":0.4373595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06288363773230682,"score_gpt":0.3423151495477254,"score_spread":0.2794315118154185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}