{"id":"W2531288146","doi":"10.1126/sciadv.1600760","title":"Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia","year":2016,"lang":"en","type":"article","venue":"Science Advances","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust; Wellcome","keywords":"Bromodomain; Biology; Transcription factor; Leukemia; Computational biology; Transcription (linguistics); Genetics; Gene; Epigenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000191615,0.0001959777,0.0002482502,0.0001442764,0.00009928813,0.0002763552,0.0001583711,0.0001690032,0.0005427685],"category_scores_gemma":[0.0001212685,0.0001161178,0.0001235799,0.000138804,0.0001954869,0.0001347299,0.0001350256,0.0004647585,0.0002210331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002990721,"about_ca_system_score_gemma":0.0001576249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002691644,"about_ca_topic_score_gemma":0.0008371749,"domain_scores_codex":[0.9998934,0.0000183587,0.000008039092,0.00002147402,0.00003444878,0.00002426033],"domain_scores_gemma":[0.9999459,0.00001425079,0.00001357615,0.000007073761,0.000004772635,0.0000144522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009708798,0.00001746838,0.0001671082,0.00001403546,0.00000149765,0.00001307949,0.00000540962,0.0000900396,0.9982773,0.00009725535,0.00001767632,0.00120198],"study_design_scores_gemma":[0.0000105072,0.0001453841,0.001792712,0.000001898268,0.00000459894,0.00009751767,0.000006500567,0.0009582533,0.9957781,0.00004124817,0.001161648,0.000001484009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910303,0.002569489,0.004143658,0.00008443264,0.00001460248,0.00002612193,0.000245077,0.00006839245,0.001817821],"genre_scores_gemma":[0.9954254,0.001066605,0.002215637,0.00004591669,0.00000458062,0.00001283801,0.0002258259,0.00001098934,0.0009921895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005427685,"threshold_uncertainty_score":0.002169907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006973314056963163,"score_gpt":0.2369279654021179,"score_spread":0.2299546513451547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}