{"id":"W2531288146","doi":"10.1126/sciadv.1600760","title":"Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia","year":2016,"lang":"en","type":"article","venue":"Science Advances","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Medical Research Council; Canadian Institutes of Health Research; Wellcome Trust; Wellcome","keywords":"Bromodomain; Biology; Transcription factor; Leukemia; Computational biology; Transcription (linguistics); Genetics; Gene; Epigenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008638765,0.0001008428,0.0001455775,0.00009902757,0.00005106355,0.00000976626,0.0002595941,0.00005416689,0.00001387317],"category_scores_gemma":[0.0003250694,0.00007261159,0.00004345305,0.000282117,0.0006473882,0.00007988011,0.00005337061,0.00003536691,0.000001588439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006066099,"about_ca_system_score_gemma":0.0002632224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001919612,"about_ca_topic_score_gemma":0.0000110021,"domain_scores_codex":[0.9987606,0.00006966513,0.0003319817,0.0003286059,0.000305965,0.0002032132],"domain_scores_gemma":[0.9994233,0.00001311766,0.0001894954,0.0002243365,0.0001013173,0.00004848762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004469136,0.00003168673,0.001497834,0.00003109821,0.000002312175,5.691482e-7,0.00008011027,0.000008674866,0.9934438,0.00002327633,0.00006271893,0.004370992],"study_design_scores_gemma":[0.0004960742,0.0003656543,0.00521435,0.00009610218,0.000001998511,0.000002293026,0.0001000626,0.000001746241,0.9905649,0.0002449357,0.002808994,0.0001028338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978032,0.0007696949,0.0006688409,0.000162497,0.0000996219,0.0002949037,0.00001936824,0.000006762365,0.0001750938],"genre_scores_gemma":[0.9975507,0.00008105247,0.001230596,0.00002135853,0.00002257246,0.00002273432,0.000009902232,0.000007587266,0.001053501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004268158,"threshold_uncertainty_score":0.2961015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006973314056963163,"score_gpt":0.2369279654021179,"score_spread":0.2299546513451547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}