{"id":"W2531315909","doi":"10.1182/blood.v126.23.800.800","title":"Prevalence and Prognostic Significance of KIT Mutations in Pediatric Core Binding Factor AML Patients Treated with Gemtuzumab Ozogamicin: Results from the Randomized Phase III Children's Oncology Group Trial AAML0531","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Population Health Research Institute; Hospital for Sick Children","funders":"","keywords":"Gemtuzumab ozogamicin; Medicine; Core binding factor; Internal medicine; Exon; Oncology; Missense mutation; CD33; Mutation; Gastroenterology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002140156,0.0004087336,0.0009860257,0.0002635552,0.0002278186,0.0006449183,0.0003847606,0.0006532877,0.0007972046],"category_scores_gemma":[0.001870665,0.0002743879,0.0008368989,0.0003466971,0.0005000526,0.0005057956,0.0002960691,0.001047315,0.0001125815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006853796,"about_ca_system_score_gemma":0.0006942078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005546953,"about_ca_topic_score_gemma":0.001137145,"domain_scores_codex":[0.9988579,0.0007079298,0.00007137622,0.0001549846,0.0001131185,0.00009475979],"domain_scores_gemma":[0.9985998,0.0004573176,0.0004826698,0.0000862932,0.0000590921,0.000314815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6436319,0.007704469,0.2702031,0.0002721059,0.002240172,0.0002185962,0.0002285123,0.001962961,0.01627558,0.0002747942,0.002039326,0.0549484],"study_design_scores_gemma":[0.2082513,0.2302409,0.5425046,0.00008571435,0.002683527,0.0007410665,0.0001914667,0.005981415,0.006101596,0.0004318865,0.002721331,0.00006511532],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991533,0.0004500947,0.00004831422,0.00006424139,0.000009351182,0.00005801927,0.0001203226,0.000003956761,0.00009231548],"genre_scores_gemma":[0.998861,0.0001953516,0.000190568,0.0001135389,0.00003305095,0.0001039536,0.0004189565,0.000002244997,0.00008136618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140156,"threshold_uncertainty_score":0.01131833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190048354597085,"score_gpt":0.3048554029148532,"score_spread":0.2729549193688824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}