{"id":"W2531339322","doi":"10.1002/cam4.845","title":"A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia","year":2016,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University Health Network","funders":"Ontario Ministry of Research and Innovation; Stem Cell Network; Cancer Center, University of Kansas; National Cancer Institute; National Institutes of Health; Leukemia and Lymphoma Society","keywords":"Tigecycline; Myeloid leukemia; Medicine; Pharmacodynamics; Pharmacology; Refractory (planetary science); Pharmacokinetics; Myeloid; Internal medicine; Antibiotics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009964962,0.001182617,0.001742512,0.0004148957,0.0004564797,0.0007034906,0.000600601,0.0009271663,0.001937994],"category_scores_gemma":[0.0009306995,0.0004932915,0.0006200916,0.0003780345,0.0008132895,0.000544372,0.0002608665,0.002626415,0.0004822853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006601895,"about_ca_system_score_gemma":0.001719261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007472108,"about_ca_topic_score_gemma":0.001347951,"domain_scores_codex":[0.9995436,0.0002074265,0.00001886376,0.00007890903,0.00004226872,0.0001089082],"domain_scores_gemma":[0.9994593,0.0001014805,0.0000764111,0.00005241785,0.00004080952,0.000269579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5290015,0.1851284,0.01279626,0.0006637376,0.0005836064,0.0005723986,0.0007519978,0.004917703,0.1033741,0.0006788116,0.003294638,0.1582368],"study_design_scores_gemma":[0.2056248,0.7765185,0.00899278,0.00001825368,0.0001261307,0.0002000257,0.00005521884,0.001028058,0.004902891,0.000152576,0.00236051,0.00002019649],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932827,0.0007613361,0.00059643,0.000258001,0.00006807292,0.003687883,0.000344655,0.00004776086,0.0009531325],"genre_scores_gemma":[0.9909644,0.001152261,0.002081315,0.0004354172,0.0001267741,0.003307583,0.0006718363,0.00001760942,0.001242731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937994,"threshold_uncertainty_score":0.006483197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01923384069786624,"score_gpt":0.3347315085748791,"score_spread":0.3154976678770128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}