{"id":"W2531356683","doi":"10.1182/blood.v108.11.3533.3533","title":"Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Two Doses of Bortezomib (Btz) in Patients with Relapsed Multiple Myeloma (MM).","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Royal Victoria Hospital","funders":"","keywords":"Pharmacokinetics; Cmax; Medicine; Pharmacodynamics; Bortezomib; Volume of distribution; Pharmacology; Multiple myeloma; Distribution (mathematics); Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007325016,0.0005103808,0.001128579,0.0002288377,0.000266844,0.0004907355,0.0002770662,0.0005777893,0.001043985],"category_scores_gemma":[0.001388785,0.0003515715,0.0006775264,0.0002684995,0.0004401242,0.0004722085,0.0002422931,0.00173153,0.0002762314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008040584,"about_ca_system_score_gemma":0.0005976745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008672394,"about_ca_topic_score_gemma":0.001180399,"domain_scores_codex":[0.9994998,0.000207245,0.00002350193,0.00009649899,0.00008964721,0.00008340641],"domain_scores_gemma":[0.9993221,0.0001447033,0.0001873209,0.00004980032,0.00003010052,0.0002661006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5821992,0.03147037,0.07142802,0.0003146936,0.00102453,0.0005533978,0.0005253206,0.006535604,0.1687627,0.0002046529,0.001526152,0.1354555],"study_design_scores_gemma":[0.05215215,0.6621098,0.2584558,0.00002840554,0.0006250179,0.0009072351,0.0001218643,0.004720981,0.01674817,0.0002621803,0.003804692,0.00006363841],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998747,0.0005015417,0.0001586035,0.00005562522,0.00001231463,0.0001091751,0.0001570638,0.00001450231,0.0002442392],"genre_scores_gemma":[0.9988012,0.0001612347,0.0002610618,0.00008812505,0.00002821563,0.0001143001,0.0002555563,0.000003855011,0.0002863632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001128579,"threshold_uncertainty_score":0.005833805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009579060015435492,"score_gpt":0.2762750528402685,"score_spread":0.266695992824833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}