{"id":"W2531369023","doi":"10.1038/cddis.2016.315","title":"DDX3 DEAD-box RNA helicase plays a central role in mitochondrial protein quality control in Leishmania","year":2016,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Cell biology; Biology; Proteostasis; HSPA9; Mitochondrion; DNAJA3; DEAD box; Unfolded protein response; RNA Helicase A; Helicase; Mitophagy; Mitochondrial ROS; mitochondrial fusion; Biochemistry; Mitochondrial DNA; Autophagy; RNA; Endoplasmic reticulum; Apoptosis; Gene; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008627187,0.0002076515,0.0001397117,0.0001298118,0.0002066334,0.0002865761,0.00009538107,0.000200999,0.000623104],"category_scores_gemma":[0.00007379879,0.00008346054,0.0002138011,0.0001180711,0.000157285,0.0001490411,0.0001768384,0.0002209885,0.0003180699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003361846,"about_ca_system_score_gemma":0.0001689389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006298496,"about_ca_topic_score_gemma":0.000630105,"domain_scores_codex":[0.9999512,0.00000681257,0.000005743279,0.00001132455,0.0000136464,0.0000113133],"domain_scores_gemma":[0.9999548,0.000004101385,0.00001398275,0.000004947224,0.000008341762,0.00001384058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000620201,0.000005595624,0.0005604028,0.00004249453,0.000004028744,0.0001063478,0.00001561787,0.00004889518,0.9978416,0.0001117827,0.00006198368,0.00113924],"study_design_scores_gemma":[0.00001909507,0.0001622089,0.0264582,0.00001683855,0.00002947568,0.001541802,0.00009681438,0.001809316,0.9621428,0.0003099937,0.007403789,0.00000975143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876271,0.004813736,0.004928024,0.0002178307,0.00002804782,0.00001903954,0.000735855,0.0001421806,0.001488284],"genre_scores_gemma":[0.9959124,0.0007999155,0.001228204,0.00005506562,0.0000045212,0.000007658337,0.0007503247,0.00001271581,0.001229235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006298496,"threshold_uncertainty_score":0.002439201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017167401971787,"score_gpt":0.2853361433244375,"score_spread":0.2681687413526505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}