{"id":"W2531387571","doi":"10.1038/srep34962","title":"FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cohesin; FOXA2; FOXA1; Transcription factor; Enhancer; Mediator; Biology; Transcription (linguistics); Cell biology; Transcriptional regulation; Gene; Genetics; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886587,0.0003048696,0.0003287789,0.0004782027,0.0003003645,0.0006102505,0.0002123412,0.0002312155,0.001580237],"category_scores_gemma":[0.0003584537,0.0003107435,0.0003648978,0.0004156069,0.000198263,0.0004431247,0.0004811204,0.0002775029,0.0005157263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004237975,"about_ca_system_score_gemma":0.0005359603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002880028,"about_ca_topic_score_gemma":0.004884518,"domain_scores_codex":[0.9998748,0.000007313324,0.000005971307,0.00005515427,0.0000311029,0.00002558352],"domain_scores_gemma":[0.9998473,0.00002425179,0.00004423283,0.00002457387,0.00003087093,0.00002878857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009223344,0.00001516737,0.01838722,0.00008378688,0.00002816397,0.0001028996,0.00008168423,0.001095609,0.966958,0.001197581,0.0003107113,0.011647],"study_design_scores_gemma":[0.00002630977,0.0001184835,0.2050892,0.00003761817,0.00007955926,0.0005146129,0.0002122303,0.02334796,0.7493958,0.002076148,0.01906822,0.00003387427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714826,0.001902783,0.02169896,0.00009939023,0.0000178611,0.00002840889,0.00245809,0.0003476362,0.001964142],"genre_scores_gemma":[0.9818459,0.0009323989,0.01114965,0.00006325274,0.00001049716,0.00002785751,0.003001766,0.0000516906,0.002916959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002880028,"threshold_uncertainty_score":0.005726576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042847415366759,"score_gpt":0.2300195927122781,"score_spread":0.2095911185586105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}