{"id":"W2531387571","doi":"10.1038/srep34962","title":"FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cohesin; FOXA2; FOXA1; Transcription factor; Enhancer; Mediator; Biology; Transcription (linguistics); Cell biology; Transcriptional regulation; Gene; Genetics; Chromatin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003683937,0.0001000899,0.0001043432,0.00003671871,0.00009913716,0.00003443084,0.00007269429,0.00007794558,0.00003348271],"category_scores_gemma":[0.00001570705,0.00006116744,0.00004682604,0.00005530172,0.0002275971,0.00000563713,0.00002747324,0.00002777484,5.648885e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001301919,"about_ca_system_score_gemma":0.00007512268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001231153,"about_ca_topic_score_gemma":0.0001450464,"domain_scores_codex":[0.9990185,0.00001910894,0.0002515423,0.0003958158,0.000173969,0.0001410673],"domain_scores_gemma":[0.9993818,0.000007687115,0.0001135185,0.0003324134,0.00007581256,0.00008876187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008626391,0.00001076653,0.01355836,0.00001831992,0.00001663913,0.000001525465,0.0002645821,0.000006573521,0.9827251,0.00003371895,0.001581345,0.001774485],"study_design_scores_gemma":[0.0002418026,0.0000700557,0.08659413,0.00005117073,0.00004006168,0.00003182632,0.0001896938,0.00002303126,0.8665524,0.0009007566,0.04510686,0.000198277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967356,0.0007291291,0.0002669927,0.0002355391,0.001733609,0.0002152936,0.00004795313,0.000003779211,0.000032161],"genre_scores_gemma":[0.9982339,0.00007871562,0.00009647854,0.00003742295,0.00005625821,0.00001486757,0.00002583903,0.00001107699,0.001445455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1161727,"threshold_uncertainty_score":0.2494336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02042847415366759,"score_gpt":0.2300195927122781,"score_spread":0.2095911185586105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}