{"id":"W2531443355","doi":"10.1128/iai.00692-16","title":"Dynamic Interactions of a Conserved Enterotoxigenic Escherichia coli Adhesin with Intestinal Mucins Govern Epithelium Engagement and Toxin Delivery","year":2016,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs; CH.I.L.D. Foundation; Government of Canada; National Institutes of Health; Tulane University","keywords":"Bacterial adhesin; Enterotoxigenic Escherichia coli; Mucin; Biology; Microbiology; Toxin; Escherichia coli; Epithelium; Intestinal epithelium; Mucin 2; Enterotoxin; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002384825,0.0001177776,0.0001239059,0.00004221138,0.0001527191,0.00001641092,0.00005153161,0.00004057549,0.00002575139],"category_scores_gemma":[0.0002272071,0.00008312604,0.00003326251,0.00007369327,0.0002382073,0.00001320358,0.0002034484,0.0001328037,0.000001770271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003190994,"about_ca_system_score_gemma":0.0000562602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006074362,"about_ca_topic_score_gemma":0.001590582,"domain_scores_codex":[0.9992434,0.0002313156,0.0001461085,0.0001656806,0.00007614079,0.000137298],"domain_scores_gemma":[0.9994653,0.00007546156,0.00008703331,0.0001791444,0.0001383427,0.00005470234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002616968,0.0001180437,0.08337267,0.00003370026,0.0001193565,6.46271e-7,0.00008474287,6.946175e-7,0.9134375,0.0000115362,0.00005071431,0.002508683],"study_design_scores_gemma":[0.001668125,0.001796089,0.7476914,0.0001621059,0.00004407177,0.00003537048,0.0003448182,0.0001457702,0.2413476,0.00002138351,0.006529632,0.0002135978],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974656,0.0002227957,0.001579599,0.0001461409,0.00004482219,0.0002226178,0.00001603983,0.00001282055,0.0002895485],"genre_scores_gemma":[0.9978085,0.001342387,0.0003637616,0.00006102219,0.00001200648,0.0000468429,0.000005856924,0.000009998424,0.0003495889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6720899,"threshold_uncertainty_score":0.3389782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754926280888258,"score_gpt":0.2709968805475176,"score_spread":0.253447617738635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}