{"id":"W2531444270","doi":"10.1212/wnl.0000000000003305","title":"Progression of brain atrophy in PSP and CBS over 6 months and 1 year","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"NIHR Cambridge Biomedical Research Centre; National Institute of Neurological Disorders and Stroke; Tau Consortium; National Institute for Health and Care Research; National Institutes of Health; FORUM Pharmaceuticals; Bristol-Myers Squibb; Eli Lilly and Company; Larry L. Hillblom Foundation; Mayo Foundation for Medical Education and Research; National Institute on Aging; TauRx Pharmaceuticals; Biogen; Genentech","keywords":"Progressive supranuclear palsy; Atrophy; Pons; Brainstem; Parkinsonism; Medicine; Psychology; Pathology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008597788,0.0003136344,0.0004943763,0.0008124707,0.0003670755,0.0003788133,0.0002556296,0.0004407182,0.0007465901],"category_scores_gemma":[0.002462585,0.0001641733,0.0003356945,0.0003426224,0.0003827149,0.0003700656,0.0003623133,0.000387325,0.0002131674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004148311,"about_ca_system_score_gemma":0.0002343954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003481523,"about_ca_topic_score_gemma":0.004103544,"domain_scores_codex":[0.9996629,0.00007848103,0.00004037832,0.000084008,0.00009203784,0.00004223157],"domain_scores_gemma":[0.9986768,0.0001769703,0.0007097668,0.0000640035,0.0001396614,0.0002326961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002754731,0.0001241708,0.9873284,0.00002550005,0.0001410422,0.0007998328,0.000272661,0.0001908019,0.001906879,0.00001690386,0.00009670651,0.006342193],"study_design_scores_gemma":[0.00003018909,0.0006542835,0.9982702,0.000003074744,0.00002465868,0.0006710628,0.00005899153,0.000111933,0.0001185209,0.00001161913,0.00004231959,0.000003020863],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996104,0.0001569506,0.00002556734,0.000009044563,0.000001766687,0.000004433275,0.00005588007,0.000003984486,0.0001320482],"genre_scores_gemma":[0.9996241,0.00004380857,0.00005060295,0.000008690562,0.000004531632,0.000005131233,0.0001769642,9.537886e-7,0.00008508548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003481523,"threshold_uncertainty_score":0.006922543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008210073482803117,"score_gpt":0.2678534061907455,"score_spread":0.2596433327079424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}