{"id":"W2531444270","doi":"10.1212/wnl.0000000000003305","title":"Progression of brain atrophy in PSP and CBS over 6 months and 1 year","year":2016,"lang":"en","type":"article","venue":"Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"NIHR Cambridge Biomedical Research Centre; National Institute of Neurological Disorders and Stroke; Tau Consortium; National Institute for Health and Care Research; National Institutes of Health; FORUM Pharmaceuticals; Bristol-Myers Squibb; Eli Lilly and Company; Larry L. Hillblom Foundation; Mayo Foundation for Medical Education and Research; National Institute on Aging; TauRx Pharmaceuticals; Biogen; Genentech","keywords":"Progressive supranuclear palsy; Atrophy; Pons; Brainstem; Parkinsonism; Medicine; Psychology; Pathology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003086911,0.00005433193,0.0001278272,0.00005273475,0.000007924081,0.000001074623,0.00001345237,0.00005267079,0.00003647795],"category_scores_gemma":[0.00002723359,0.00003301524,0.00001321898,0.00002761861,0.00005017854,0.00001920052,0.00002782385,0.00003401683,0.000003580643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003185526,"about_ca_system_score_gemma":0.000009166562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002286509,"about_ca_topic_score_gemma":0.00001277816,"domain_scores_codex":[0.999598,0.00003094797,0.00007043469,0.0001518019,0.00005365424,0.00009521137],"domain_scores_gemma":[0.9997833,0.00004111711,0.0000265345,0.00008472782,0.000007238323,0.00005702505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001659566,0.0001931994,0.8975527,0.00003104785,0.00002237599,0.000341656,0.00005551172,3.981345e-8,0.04377472,0.0006258858,0.0001900277,0.05555325],"study_design_scores_gemma":[0.003768845,0.001736107,0.9885457,0.00002455353,0.00002004383,0.00002828031,0.000001071137,0.00001784762,0.001055814,0.0008697786,0.003899945,0.00003204756],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971697,0.000275026,0.000005075428,0.002175586,0.00003204692,0.0001328459,0.000007824711,0.000007770107,0.000194151],"genre_scores_gemma":[0.9992392,0.00009616525,0.0001129834,0.0004733028,0.00001628453,0.000008194524,0.000001136354,0.000006849373,0.00004586152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09099296,"threshold_uncertainty_score":0.1346322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008210073482803117,"score_gpt":0.2678534061907455,"score_spread":0.2596433327079424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}