{"id":"W2531449940","doi":"10.1158/2159-8290.cd-16-0975","title":"<i>CREBBP</i> Inactivation Promotes the Development of HDAC3-Dependent Lymphomas","year":2016,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"HDAC3; Computational biology; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001364247,0.0003984149,0.0002532667,0.0002479162,0.0001329818,0.0003266827,0.0002367192,0.0002532271,0.003063857],"category_scores_gemma":[0.00009485581,0.0001456835,0.0003073587,0.0001297883,0.0002686854,0.0001309993,0.0002301244,0.0008285278,0.001143616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649124,"about_ca_system_score_gemma":0.0001908406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019116,"about_ca_topic_score_gemma":0.001426348,"domain_scores_codex":[0.9998279,0.00001757867,0.000012357,0.00003360649,0.00004300386,0.00006547882],"domain_scores_gemma":[0.9998529,0.00001584805,0.00005372669,0.00001663531,0.00001043148,0.00005039009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001164322,0.00003123752,0.0002046897,0.00002075459,0.000005496277,0.00005188184,0.000004688499,0.00004146077,0.9982498,0.00008093382,0.0001255998,0.001067011],"study_design_scores_gemma":[0.00002995702,0.000203872,0.005987923,0.000006804006,0.00001600492,0.0004547923,0.00001549571,0.0008635764,0.9887267,0.0000521596,0.003638265,0.000004615304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851922,0.002049388,0.004842277,0.0002616522,0.00007234993,0.00004776665,0.001522187,0.0008713626,0.005140936],"genre_scores_gemma":[0.9938735,0.000421731,0.001210734,0.0001014781,0.00001867935,0.00002963802,0.0009595098,0.00009674361,0.003287865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003063857,"threshold_uncertainty_score":0.01024961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506601086359499,"score_gpt":0.2797760310984957,"score_spread":0.2647100202349008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}