{"id":"W2531606342","doi":"10.1093/biolreprod/81.s1.141","title":"A Major Source of Methyl Groups in Blastocysts May Be Betaine Stored by Pre-Implantation Embryos until Betaine Homocysteine Methyltransferase (BHMT) Is Transiently Expressed at High Levels in the Inner Cell Mass.","year":2009,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Betaine; Methyltransferase; Methylation; Blastocyst; Biology; Inner cell mass; DNA methylation; Embryo; Homocysteine; Biochemistry; Molecular biology; Cell biology; Gene expression; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001683466,0.0002565567,0.0006735086,0.0005333764,0.00005833841,0.000005607604,0.0002052385,0.0002864402,0.00008284293],"category_scores_gemma":[0.0001584903,0.0001881646,0.0001253417,0.0008027829,0.0002475533,0.0001256478,0.00001819938,0.0003700075,0.000003292139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001123869,"about_ca_system_score_gemma":0.00006713678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009514961,"about_ca_topic_score_gemma":0.0001066945,"domain_scores_codex":[0.9971216,0.0005684596,0.0007947821,0.0007496785,0.0003688516,0.0003966717],"domain_scores_gemma":[0.9986963,0.000147716,0.0002061327,0.0006910487,0.0001944943,0.00006429465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00223196,0.0006385658,0.003541221,0.0002420455,0.00006899939,0.00001290232,0.003479494,0.00005530297,0.9807849,0.00002204475,0.0005216552,0.0084009],"study_design_scores_gemma":[0.005393104,0.002430986,0.06990968,0.00007156159,0.0001155762,0.00005107302,0.0006093456,0.00006315812,0.9187475,0.0001472968,0.002282657,0.0001780738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882194,0.002193641,0.0008673705,0.00710941,0.00008948323,0.001307605,0.0001245647,0.00002519643,0.00006331419],"genre_scores_gemma":[0.997331,0.000272825,0.0006130603,0.0001468432,0.0001078878,0.00005596463,0.0004159232,0.00002142793,0.001035076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06636845,"threshold_uncertainty_score":0.7673128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114321461942817,"score_gpt":0.2905447412706783,"score_spread":0.2694015266512501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}