{"id":"W2531606342","doi":"10.1093/biolreprod/81.s1.141","title":"A Major Source of Methyl Groups in Blastocysts May Be Betaine Stored by Pre-Implantation Embryos until Betaine Homocysteine Methyltransferase (BHMT) Is Transiently Expressed at High Levels in the Inner Cell Mass.","year":2009,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Betaine; Methyltransferase; Methylation; Blastocyst; Biology; Inner cell mass; DNA methylation; Embryo; Homocysteine; Biochemistry; Molecular biology; Cell biology; Gene expression; Embryogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002643076,0.0004784473,0.0003923992,0.0003129886,0.0003499415,0.0004011627,0.0003041104,0.000483228,0.002266382],"category_scores_gemma":[0.0002303988,0.0002677053,0.0002205496,0.0002071492,0.0002273156,0.0004560446,0.0002157002,0.0006460302,0.001224671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981136,"about_ca_system_score_gemma":0.0003120783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006419016,"about_ca_topic_score_gemma":0.0009760569,"domain_scores_codex":[0.9998531,0.00001848167,0.00001013359,0.0000583119,0.0000432424,0.00001671166],"domain_scores_gemma":[0.9998111,0.00005114664,0.00004991368,0.00002269789,0.00003518739,0.00002997051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006463588,0.000005673226,0.000685004,0.0000504418,0.00000616655,0.00005241167,0.00002306145,0.00001902687,0.9954208,0.00008369341,0.00002595885,0.003563114],"study_design_scores_gemma":[0.000005725277,0.0001498056,0.01372677,0.00002883195,0.00002136078,0.0003113607,0.00005172409,0.0001925202,0.9796544,0.00010183,0.005748478,0.000007194425],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9010408,0.0208866,0.06024875,0.0005197854,0.0001865108,0.0001407586,0.003562837,0.0007162539,0.01269772],"genre_scores_gemma":[0.9269588,0.01018537,0.03985707,0.0004223502,0.0000962256,0.0001573302,0.003595801,0.0002132185,0.01851386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002266382,"threshold_uncertainty_score":0.00758177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114321461942817,"score_gpt":0.2905447412706783,"score_spread":0.2694015266512501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}