{"id":"W2531690304","doi":"10.1016/j.celrep.2016.09.049","title":"MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Biology; Translation (biology); microRNA; RNA-binding protein; Untranslated region; RNA; Induced pluripotent stem cell; Cell biology; Messenger RNA; Translational regulation; Gene isoform; Three prime untranslated region; Embryonic stem cell; Genetics; Computational biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008402184,0.0001451899,0.0001179296,0.00004111582,0.0001003987,0.00001154232,0.00005975004,0.00009934843,0.00003373762],"category_scores_gemma":[0.00001570184,0.0001256782,0.00004691827,0.00004426739,0.00005465668,0.000005812029,0.00006648859,0.00004133091,9.460264e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001570779,"about_ca_system_score_gemma":0.00005412942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001267352,"about_ca_topic_score_gemma":0.000006410374,"domain_scores_codex":[0.9989078,0.00002183499,0.0003270446,0.0003886172,0.0001794132,0.0001752832],"domain_scores_gemma":[0.9994571,0.000002480669,0.000190121,0.000189954,0.00008704363,0.00007325893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003995371,0.0000712363,0.001842651,0.00004024167,0.0000208274,0.000008616654,0.00004705118,4.588505e-7,0.9968868,0.000005004717,0.0006426604,0.0003944606],"study_design_scores_gemma":[0.0005589669,0.0001376125,0.05758562,0.00002339501,0.000009017626,0.00003688367,0.00001591217,1.798902e-7,0.9366633,0.0000777625,0.004732816,0.000158584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987108,0.0001412659,0.00003211594,0.0001099574,0.0003311554,0.0002459602,0.00001332839,0.000009379946,0.0004060218],"genre_scores_gemma":[0.9973808,0.0002079299,0.0001024203,0.00003847138,0.0000171877,0.00001545448,0.0000705433,0.00002355948,0.002143653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06022358,"threshold_uncertainty_score":0.5125007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007675105226591394,"score_gpt":0.2129612300119064,"score_spread":0.205286124785315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}