{"id":"W2531690304","doi":"10.1016/j.celrep.2016.09.049","title":"MECP2 Is Post-transcriptionally Regulated during Human Neurodevelopment by Combinatorial Action of RNA-Binding Proteins and miRNAs","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Biology; Translation (biology); microRNA; RNA-binding protein; Untranslated region; RNA; Induced pluripotent stem cell; Cell biology; Messenger RNA; Translational regulation; Gene isoform; Three prime untranslated region; Embryonic stem cell; Genetics; Computational biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292512,0.0001873035,0.0001771325,0.0001825213,0.0001275255,0.000303763,0.00008739959,0.0001214536,0.0003625078],"category_scores_gemma":[0.0001762584,0.0001460084,0.0001336905,0.0001347565,0.0001646891,0.000124016,0.0001760314,0.0001922389,0.0001596992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002815491,"about_ca_system_score_gemma":0.0001899183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005391532,"about_ca_topic_score_gemma":0.00084551,"domain_scores_codex":[0.9998779,0.00001463091,0.000009423798,0.00003977808,0.00003181697,0.00002639204],"domain_scores_gemma":[0.9999202,0.00001373103,0.00003008556,0.000007847964,0.00001395191,0.00001414664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008478298,0.000002766906,0.001508926,0.00001490788,0.000006699875,0.0001088312,0.00001804125,0.00006514457,0.9957615,0.0001042485,0.00003244439,0.002291798],"study_design_scores_gemma":[0.000005142899,0.00006003802,0.04020848,0.000005790898,0.00002731596,0.0008062317,0.00003259647,0.0006833905,0.9557385,0.0001230034,0.002303717,0.00000573646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916872,0.003679422,0.003246718,0.00006311588,0.00001343365,0.0000109412,0.0003017861,0.00007976731,0.000917483],"genre_scores_gemma":[0.9966126,0.0005908505,0.001454502,0.00003604259,0.000007069922,0.00001310086,0.0002648206,0.00001680712,0.001004194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005391532,"threshold_uncertainty_score":0.00204277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007675105226591394,"score_gpt":0.2129612300119064,"score_spread":0.205286124785315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}