{"id":"W2531709463","doi":"10.1021/acsomega.6b00120","title":"Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins","year":2016,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Prostate Cancer Canada; Cancer Research Society","keywords":"Selectivity; Chemistry; Structure–activity relationship; Computational biology; Biochemistry; Stereochemistry; Pharmacology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134789,0.0005075434,0.0004316311,0.0002136578,0.0001420097,0.0002085134,0.0003204082,0.00024486,0.002212324],"category_scores_gemma":[0.0001234168,0.0001392045,0.0002355756,0.0002151528,0.000118571,0.0001952503,0.0001096322,0.0005294326,0.000449202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003863931,"about_ca_system_score_gemma":0.0001920412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009450498,"about_ca_topic_score_gemma":0.00153102,"domain_scores_codex":[0.999887,0.00001799042,0.000007942072,0.00002090072,0.00003751829,0.00002862328],"domain_scores_gemma":[0.9999392,0.00001385666,0.00001257965,0.000003992142,0.00001435386,0.00001597755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002843667,0.0001509376,0.0001099058,0.00005372595,0.00001403153,0.00003109769,0.00001205295,0.0007940113,0.9938537,0.00006277728,0.0001704864,0.00446301],"study_design_scores_gemma":[0.0001132175,0.00354265,0.001475542,0.00000589295,0.00003987021,0.0001967473,0.00001751656,0.004264209,0.9874659,0.00003601465,0.002828666,0.00001377715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818313,0.005826045,0.004919651,0.0002128775,0.00004070029,0.0001728384,0.001156956,0.00017864,0.005660881],"genre_scores_gemma":[0.9821796,0.003917292,0.005758598,0.0001388939,0.00002032657,0.0001082301,0.002086808,0.00002989408,0.005760334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212324,"threshold_uncertainty_score":0.00740093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673764819205584,"score_gpt":0.3089445940922761,"score_spread":0.2722069459002203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}