{"id":"W2531709463","doi":"10.1021/acsomega.6b00120","title":"Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins","year":2016,"lang":"en","type":"article","venue":"ACS Omega","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Prostate Cancer Canada; Cancer Research Society","keywords":"Selectivity; Chemistry; Structure–activity relationship; Computational biology; Biochemistry; Stereochemistry; Pharmacology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002740454,0.0001713702,0.0002294039,0.00007720292,0.0001586528,0.000007551741,0.000107789,0.0001739503,2.557462e-7],"category_scores_gemma":[0.0005796972,0.0001127208,0.00008517021,0.0002018889,0.0001986434,0.0000131558,0.0001397326,0.0001113491,8.388158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000463004,"about_ca_system_score_gemma":0.00003951324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001030247,"about_ca_topic_score_gemma":0.0001430216,"domain_scores_codex":[0.9989741,0.0001401456,0.0002036638,0.0003405539,0.000147097,0.0001944145],"domain_scores_gemma":[0.9991616,0.00005311719,0.0002080108,0.000347424,0.0001900834,0.00003979193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004248184,0.00003958863,0.008842323,0.00001432144,0.0001242646,6.139396e-7,0.00002733459,0.000001669504,0.9807379,0.00004518739,0.0003340605,0.009790216],"study_design_scores_gemma":[0.0002097043,0.0001169584,0.001673114,0.00005967412,0.00002435443,0.000002532183,0.00002854337,0.00000232167,0.9949203,0.0007156868,0.002072146,0.0001746707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972076,0.0003104046,0.001700174,0.0002785836,0.00004369064,0.0001808869,0.00004415309,0.00004454161,0.0001899391],"genre_scores_gemma":[0.9970154,0.0001798042,0.002295138,0.00005190186,0.000170628,0.000008844298,0.000007992316,0.00002042068,0.0002498604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01418236,"threshold_uncertainty_score":0.459662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03673764819205584,"score_gpt":0.3089445940922761,"score_spread":0.2722069459002203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}