{"id":"W2531713013","doi":"10.1038/cgt.2016.41","title":"Expression of the fusogenic p14 FAST protein from a replication-defective adenovirus vector does not provide a therapeutic benefit in an immunocompetent mouse model of cancer","year":2016,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Government of Ontario; Cancer Research Society","keywords":"Biology; Viral vector; Cancer research; Fusion protein; Multiplicity of infection; Cell biology; Molecular biology; Virology; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382872,0.0002583767,0.0003012797,0.00006742791,0.00006770123,0.00001176297,0.0007379362,0.0001617804,0.00008951195],"category_scores_gemma":[0.00001420994,0.0001417194,0.0001703009,0.0001568504,0.000197612,0.00001596822,0.0001162109,0.0001205427,9.863803e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001459104,"about_ca_system_score_gemma":0.000508562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032876,"about_ca_topic_score_gemma":0.003852764,"domain_scores_codex":[0.9980407,0.0002173094,0.0004150622,0.0006760302,0.0003247935,0.0003260704],"domain_scores_gemma":[0.9978186,0.00002267959,0.0003140329,0.00152368,0.0002519631,0.00006902814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006994686,0.0001915108,0.004370369,0.00001212911,0.0001472002,1.034049e-7,0.0004144037,0.0009532967,0.9500441,0.00001091247,0.000002497025,0.03685879],"study_design_scores_gemma":[0.002147865,0.0008230821,0.004648578,0.00009205001,0.00001208739,1.40285e-7,0.00003569185,0.0001838553,0.9914478,0.0003156535,0.00007702104,0.0002161657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898087,0.007348326,0.0002247055,0.0003332373,0.00005382022,0.001471329,0.0007426251,0.00001193585,0.000005346718],"genre_scores_gemma":[0.9936361,0.003665094,0.0001250808,0.0002067234,0.0001255547,0.001734854,0.00001629154,0.00006667198,0.0004236042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0414037,"threshold_uncertainty_score":0.5779151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02854886913977417,"score_gpt":0.3103279438467393,"score_spread":0.2817790747069652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}