{"id":"W2531723709","doi":"10.1038/onc.2016.361","title":"Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Biology; Transactivation; Cytotoxicity; Cancer research; Complementation; Intracellular; Cytotoxic T cell; Cell biology; Function (biology); Biochemistry; In vitro; Gene; Mutant; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006151258,0.0001461077,0.000406539,0.00005812838,0.0000384359,0.000007684862,0.00004719248,0.000159542,0.000120813],"category_scores_gemma":[0.0009347796,0.0001069164,0.00009677684,0.00009220633,0.00008896167,0.00006393691,0.00005363258,0.0001370421,0.00002492741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007106207,"about_ca_system_score_gemma":0.0001349768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005758705,"about_ca_topic_score_gemma":0.000006283834,"domain_scores_codex":[0.9986187,0.0001045409,0.0004607461,0.0003383014,0.0002637882,0.0002139291],"domain_scores_gemma":[0.9989475,0.0002818524,0.0002706972,0.0002504276,0.0001104202,0.0001390942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002924223,0.0001019919,0.002772859,0.00004356686,0.00009751171,0.0000225388,0.00005991682,4.398558e-7,0.979232,0.00005811093,0.00236484,0.0149538],"study_design_scores_gemma":[0.00308822,0.0005607262,0.0006988771,0.0002284918,0.0001897934,0.00004109822,0.00006852985,0.00005695346,0.9886502,0.000149367,0.006124109,0.0001436292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919613,0.0006100824,0.005264911,0.0005351382,0.0002026105,0.0002906772,0.00005381136,0.00005262943,0.001028845],"genre_scores_gemma":[0.9965411,0.000404924,0.00199527,0.00009160769,0.0001663281,0.00001261436,0.00006734663,0.00003783092,0.0006829067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01481017,"threshold_uncertainty_score":0.4359924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04250874505415007,"score_gpt":0.3253208668560048,"score_spread":0.2828121218018547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}