{"id":"W2531730587","doi":"10.1182/blood.v118.21.3606.3606","title":"A Phase I Combination Study of Ribavirin and Low Dose Cytarabine Arabinoside (ara-C) in M4/M5 Acute Myeloid Leukemia (AML) and AML with High eIF4E,","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Institute for Research in Immunology and Cancer; McGill University; Jewish General Hospital","funders":"","keywords":"Cytarabine; Medicine; EIF4E; Ribavirin; Myeloid leukemia; Oncology; Cancer; Cancer research; Leukemia; Myeloid; Internal medicine; Temozolomide; Chemotherapy; Immunology; Translation (biology); Biology; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001057888,0.001510526,0.001729488,0.0006055408,0.0003965376,0.0009640157,0.001159813,0.001509428,0.003207805],"category_scores_gemma":[0.0006190608,0.0006704825,0.001305012,0.0004287956,0.001043598,0.0008459505,0.0003110316,0.003144185,0.0007639527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008097042,"about_ca_system_score_gemma":0.001348428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127027,"about_ca_topic_score_gemma":0.002307176,"domain_scores_codex":[0.999673,0.000123042,0.00001704592,0.00006068158,0.00003364152,0.0000926381],"domain_scores_gemma":[0.9994864,0.0000734868,0.00006896741,0.00005458128,0.00002951586,0.0002869745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5892444,0.2344875,0.002431953,0.0008641228,0.001486192,0.0003041222,0.0003612746,0.00290077,0.08001921,0.0009233414,0.004075868,0.08290119],"study_design_scores_gemma":[0.3028039,0.6824809,0.004439097,0.00002904759,0.0002819555,0.0001613933,0.00007194821,0.001162391,0.005304658,0.0002398226,0.002997058,0.00002777848],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884427,0.002567995,0.0009412865,0.000493062,0.0003583816,0.003954605,0.0008939497,0.0001216731,0.002226482],"genre_scores_gemma":[0.9866058,0.002505802,0.00198534,0.0006729516,0.0002164254,0.002855635,0.001394231,0.00002599294,0.00373787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003207805,"threshold_uncertainty_score":0.01073116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291836587378794,"score_gpt":0.2423963824091339,"score_spread":0.2294780165353459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}