{"id":"W2531792466","doi":"10.1002/acn3.369","title":"Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases","year":2016,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Hjartavernd; Medical Research Council; Labex; Fondation Brain Canada; Alzheimer’s Research UK; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Erasmus Medisch Centrum; Government of Canada; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Fulbright Canada; Centre hospitalier régional universitaire de Lille; Wellcome; Weston Brain Institute; Wellcome Trust; National Institute on Aging; Alzheimer's Association","keywords":"Genome-wide association study; Immune system; Amyotrophic lateral sclerosis; Acquired immune system; Innate immune system; Heritability; Disease; Parkinson's disease; Medicine; Missing heritability problem; Multiple sclerosis; Biology; Gene; Immunology; Genetics; Pathology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002512863,0.0001148345,0.0002595504,0.00008480525,0.00006769582,0.00001139308,0.00007684197,0.00008214478,0.00001575963],"category_scores_gemma":[0.0002865256,0.00008575318,0.0000436185,0.00007519348,0.0004951076,0.0001650357,0.00004577089,0.0001373068,0.000002131779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":9.370814e-8,"about_ca_system_score_gemma":0.00002721796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004622351,"about_ca_topic_score_gemma":0.00001319496,"domain_scores_codex":[0.9984219,0.0004177523,0.0005215679,0.0003901663,0.0001021332,0.0001464722],"domain_scores_gemma":[0.9975948,0.002007601,0.0001376176,0.0001054466,0.00003414544,0.0001204355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00404244,0.0005033119,0.3759748,0.00002913534,0.0000575796,0.00005782895,0.0002139747,0.00004417016,0.1894874,0.2286493,0.0001017991,0.2008382],"study_design_scores_gemma":[0.001559613,0.0005009111,0.8755532,0.000007373953,0.0000200362,0.00003413807,0.000001883812,0.001003083,0.05548814,0.0621993,0.003481631,0.0001507213],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815804,0.0003270934,0.0001309459,0.0175763,0.00006728086,0.0001482336,0.00008567888,0.00001741647,0.00006669225],"genre_scores_gemma":[0.992395,0.003458374,0.00006128594,0.004026507,0.00003549128,0.000007318656,0.000001669432,0.000008889836,0.000005494021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4995783,"threshold_uncertainty_score":0.3496913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1825651013219081,"score_gpt":0.3769747935341149,"score_spread":0.1944096922122068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}