{"id":"W2531792466","doi":"10.1002/acn3.369","title":"Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases","year":2016,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Hjartavernd; Medical Research Council; Labex; Fondation Brain Canada; Alzheimer’s Research UK; Institut National de la Santé et de la Recherche Médicale; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Erasmus Medisch Centrum; Government of Canada; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Fulbright Canada; Centre hospitalier régional universitaire de Lille; Wellcome; Weston Brain Institute; Wellcome Trust; National Institute on Aging; Alzheimer's Association","keywords":"Genome-wide association study; Immune system; Amyotrophic lateral sclerosis; Acquired immune system; Innate immune system; Heritability; Disease; Parkinson's disease; Medicine; Missing heritability problem; Multiple sclerosis; Biology; Gene; Immunology; Genetics; Pathology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007315365,0.0003421491,0.0003550525,0.001084087,0.0002191464,0.0004333933,0.0001819584,0.0002443206,0.001211216],"category_scores_gemma":[0.001012635,0.0001334232,0.0004647609,0.0007461477,0.0003267699,0.0003017592,0.0004679113,0.0002943481,0.0001172313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002165172,"about_ca_system_score_gemma":0.0002754364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069295,"about_ca_topic_score_gemma":0.001671649,"domain_scores_codex":[0.9995645,0.00008061283,0.00003510233,0.000209168,0.00007176626,0.00003882933],"domain_scores_gemma":[0.9991682,0.0002795898,0.0003455686,0.00006706388,0.0000797643,0.00005982069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001421387,0.000100485,0.6819925,0.0009619473,0.001480576,0.0008209223,0.0006783401,0.001932684,0.2537062,0.002218885,0.0007333403,0.05395266],"study_design_scores_gemma":[0.0000240938,0.0001181681,0.9886215,0.00004635794,0.000332546,0.0006425409,0.0001053485,0.001141559,0.004656599,0.002944432,0.001353329,0.00001355883],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891292,0.004016284,0.003567656,0.0002824788,0.00001419795,0.00001120365,0.001875691,0.00006310017,0.001040268],"genre_scores_gemma":[0.994055,0.001015752,0.003352663,0.0001716397,0.00002726847,0.00001471273,0.000951432,0.00001458499,0.0003970304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211216,"threshold_uncertainty_score":0.004051983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1825651013219081,"score_gpt":0.3769747935341149,"score_spread":0.1944096922122068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}