{"id":"W2531838349","doi":"10.1021/acs.joc.6b01845","title":"Diastereoselective Synthesis of C2′-Fluorinated Nucleoside Analogues Using an Acyclic Approach","year":2016,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Terry Fox Research Institute; Fonds Québécois de la Recherche sur la Nature et les Technologies; Western Canada Research Grid; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Chemistry; Moiety; Nucleobase; Stereochemistry; Nucleoside; Alkyl; SN2 reaction; Alkylation; Fluorine; Combinatorial chemistry; Organic chemistry; DNA; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592319,0.0006824014,0.000298165,0.0003322459,0.0001954293,0.0002914215,0.0003291568,0.0003832216,0.002507463],"category_scores_gemma":[0.0001609488,0.0001887987,0.0002609633,0.000270466,0.0001363617,0.0002164813,0.0002258106,0.0004653876,0.000762284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003880724,"about_ca_system_score_gemma":0.0004511341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175305,"about_ca_topic_score_gemma":0.00274485,"domain_scores_codex":[0.9998353,0.00003291935,0.00001511087,0.000036072,0.00002152616,0.00005906621],"domain_scores_gemma":[0.9999249,0.00001210273,0.00001774063,0.00001129922,0.00001417096,0.00001969532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002162001,0.00008651141,0.000176906,0.0001799891,0.00002397727,0.0004958297,0.0001011984,0.001015886,0.9824049,0.001468572,0.0004348688,0.01339518],"study_design_scores_gemma":[0.00004872185,0.0009641881,0.0007930507,0.00001355981,0.00002995972,0.0006068956,0.00002275985,0.0006944005,0.9805885,0.0001462437,0.01606261,0.00002913102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.915638,0.004472087,0.03395908,0.0002143901,0.0002435775,0.000584227,0.003155058,0.0006561006,0.04107741],"genre_scores_gemma":[0.9704998,0.002410937,0.01893788,0.0001376048,0.00002970775,0.0001441298,0.001370329,0.00006153441,0.00640804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002507463,"threshold_uncertainty_score":0.008388221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09039189851792845,"score_gpt":0.3757973939279106,"score_spread":0.2854054954099821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}