{"id":"W2531859512","doi":"10.1093/annonc/mdw412","title":"Randomized phase II study of modified FOLFOX-6 in combination with ramucirumab or icrucumab as second-line therapy in patients with metastatic colorectal cancer after disease progression on first-line irinotecan-based therapy","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakeridge Health; McGill University; Regional Municipality of Durham; Hamilton Health Sciences; Kelowna General Hospital; Sunnybrook Health Science Centre; Trillium Health Centre; Juravinski Cancer Centre; Mount Sinai Hospital; Nova Scotia Cancer Centre; Ottawa Hospital; BC Cancer Agency","funders":"Eli Lilly and Company","keywords":"Ramucirumab; Medicine; Oncology; Internal medicine; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002380026,0.002293722,0.005451557,0.0005826476,0.0005859972,0.00160556,0.001438246,0.002003855,0.006614171],"category_scores_gemma":[0.001654847,0.001317869,0.002621432,0.0006072663,0.001892532,0.001591981,0.0005856446,0.005241439,0.001410862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001700952,"about_ca_system_score_gemma":0.002275631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002017664,"about_ca_topic_score_gemma":0.00475015,"domain_scores_codex":[0.9991384,0.000425227,0.00003983039,0.0001853795,0.00004872012,0.0001624586],"domain_scores_gemma":[0.9987771,0.0002354418,0.0002271945,0.0001488011,0.0000755995,0.0005358678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9788569,0.009218798,0.0004112858,0.0001948916,0.0007054769,0.00002376141,0.00003456995,0.0003686168,0.002042415,0.0000715583,0.0005332321,0.007538461],"study_design_scores_gemma":[0.9356102,0.06211919,0.0008790374,0.00000945541,0.0003494887,0.00001914243,0.00001205735,0.0002698987,0.0002545382,0.00005907857,0.000406438,0.00001156896],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986439,0.002878895,0.001012681,0.0008361883,0.0009783893,0.004207033,0.001319876,0.000187904,0.002140094],"genre_scores_gemma":[0.9813711,0.002329302,0.002879307,0.001470107,0.0007355679,0.004836919,0.001939063,0.00006756568,0.00437097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006614171,"threshold_uncertainty_score":0.02212662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06133612399779004,"score_gpt":0.3986167426972846,"score_spread":0.3372806186994945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}