{"id":"W2531887049","doi":"10.1038/nature19823","title":"A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":547,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Health Sciences Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Ontario Ministry of Research and Innovation; Hebrew University of Jerusalem; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Hospital for Sick Children; Wellcome Trust","keywords":"Pancreatic cancer; Carcinogenesis; CDKN2A; Biology; Lineage (genetic); Cancer; Cancer research; Chromothripsis; Pancreatic Intraepithelial Neoplasia; KRAS; Somatic evolution in cancer; Mutation; Genetics; Genome instability; Gene; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001704963,0.0003544323,0.0006421504,0.001174699,0.0007160297,0.002679976,0.001343893,0.001899352,0.00478213],"category_scores_gemma":[0.004003317,0.0003215726,0.0006015484,0.0007863857,0.002692808,0.00519786,0.001262129,0.001597883,0.0008345494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001217614,"about_ca_system_score_gemma":0.0007344062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001527804,"about_ca_topic_score_gemma":0.001213456,"domain_scores_codex":[0.9991779,0.0002658876,0.00003499017,0.0003142546,0.0001129031,0.00009403725],"domain_scores_gemma":[0.9983597,0.0007357066,0.0002075079,0.0003400853,0.0001973725,0.0001595874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"observational","study_design_scores_codex":[0.000684155,0.0001345262,0.1148448,0.0006818674,0.0006016389,0.002601682,0.003897003,0.07855241,0.08497404,0.4782278,0.007580627,0.2272195],"study_design_scores_gemma":[0.00007361115,0.0005171053,0.062622,0.0002344792,0.0002593974,0.004182809,0.002457639,0.1493654,0.007479725,0.6986248,0.07396203,0.0002210455],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7271809,0.01112295,0.1711563,0.02929792,0.000723695,0.00007557793,0.001205802,0.0008764471,0.05836051],"genre_scores_gemma":[0.9727277,0.004304535,0.01507352,0.001948823,0.0004339001,0.00004408484,0.0003649727,0.0001624335,0.004940064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00478213,"threshold_uncertainty_score":0.01599783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722973348533786,"score_gpt":0.3378341852894211,"score_spread":0.3106044518040832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}