{"id":"W2531887049","doi":"10.1038/nature19823","title":"A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":547,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Health Sciences Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; Ontario Ministry of Research and Innovation; Hebrew University of Jerusalem; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Hospital for Sick Children; Wellcome Trust","keywords":"Pancreatic cancer; Carcinogenesis; CDKN2A; Biology; Lineage (genetic); Cancer; Cancer research; Chromothripsis; Pancreatic Intraepithelial Neoplasia; KRAS; Somatic evolution in cancer; Mutation; Genetics; Genome instability; Gene; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072814,0.0001010417,0.0003125145,0.0001193354,0.00002970735,0.000001809886,0.00007893993,0.000501157,0.0004143265],"category_scores_gemma":[0.0001338003,0.0000589568,0.00006941264,0.00008183771,0.00005153406,0.00002001742,0.000017924,0.0004396309,0.00001748159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003830766,"about_ca_system_score_gemma":0.0004778255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001218664,"about_ca_topic_score_gemma":0.00006369946,"domain_scores_codex":[0.999029,0.00004810133,0.0001700461,0.0002010417,0.0003423634,0.0002093886],"domain_scores_gemma":[0.9992818,0.00010966,0.00006765786,0.0003185628,0.00013131,0.00009101273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001692923,0.00028182,0.7409201,0.0002513953,0.0001628925,0.00001424148,0.00009772526,0.0001862262,0.2457106,0.0007186636,0.005475229,0.004488115],"study_design_scores_gemma":[0.007666163,0.0009803546,0.8908556,0.001635884,0.0004962784,0.000004712795,0.0000387383,0.08994845,0.006669672,0.000932068,0.0005696137,0.0002024953],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865282,0.0004481614,0.003832767,0.005338621,0.00006584849,0.0004147805,0.00008783141,0.00002398134,0.003259817],"genre_scores_gemma":[0.9947423,0.0001945847,0.0009995408,0.0007352286,0.0001023953,0.00007154381,0.000009537077,0.00001487903,0.00312998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.239041,"threshold_uncertainty_score":0.4536585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02722973348533786,"score_gpt":0.3378341852894211,"score_spread":0.3106044518040832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}