{"id":"W2531923638","doi":"10.1021/acs.jmedchem.6b01194","title":"Design and Discovery of Functionally Selective Serotonin 2C (5-HT<sub>2C</sub>) Receptor Agonists","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Mental Health","keywords":"Chemistry; Functional selectivity; Agonist; Arrestin; Serotonin; 5-HT2C receptor; Serotonergic; 5-HT receptor; Receptor; Pharmacology; Desensitization (medicine); G protein-coupled receptor; Partial agonist; Intrinsic activity; Signal transduction; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006767543,0.0001860101,0.0003144683,0.00003544506,0.00005406789,0.0000155474,0.0001697979,0.0002029138,0.00006926039],"category_scores_gemma":[0.0002610492,0.0001244833,0.0001275437,0.00006835957,0.0001373566,0.00001985111,0.00005050138,0.00018356,0.000001267284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004739818,"about_ca_system_score_gemma":0.0003111333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001219184,"about_ca_topic_score_gemma":2.549329e-7,"domain_scores_codex":[0.9986475,0.00006415594,0.0004743375,0.0002280032,0.0003795727,0.0002064162],"domain_scores_gemma":[0.9987826,0.00007609665,0.000505487,0.0001431864,0.0003399444,0.0001527321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007723207,0.00005449105,0.0003193688,0.00005945568,0.0001593211,0.000009967678,0.0000373724,0.00002010887,0.9936273,0.000007609754,0.001795241,0.003137485],"study_design_scores_gemma":[0.001213027,0.0007045075,0.000229866,0.0002711702,0.00005775118,0.0003197398,0.0001034821,0.000007229254,0.9956171,0.0001863685,0.001139482,0.0001502843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503779,0.001508241,0.0473654,0.0002940747,0.0002065736,0.00008992363,0.000009544596,0.000003286935,0.0001450502],"genre_scores_gemma":[0.9960313,0.001079385,0.00164115,0.000075653,0.000782579,0.000005109606,0.000006976936,0.00002234818,0.0003554713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04572425,"threshold_uncertainty_score":0.5076281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0075907545780319,"score_gpt":0.2174638975426776,"score_spread":0.2098731429646457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}