{"id":"W2531923638","doi":"10.1021/acs.jmedchem.6b01194","title":"Design and Discovery of Functionally Selective Serotonin 2C (5-HT<sub>2C</sub>) Receptor Agonists","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Mental Health","keywords":"Chemistry; Functional selectivity; Agonist; Arrestin; Serotonin; 5-HT2C receptor; Serotonergic; 5-HT receptor; Receptor; Pharmacology; Desensitization (medicine); G protein-coupled receptor; Partial agonist; Intrinsic activity; Signal transduction; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117842,0.0003181233,0.0003643087,0.0002554057,0.0001254458,0.0002269968,0.0002963473,0.0002390387,0.0009800886],"category_scores_gemma":[0.00009405159,0.0001722305,0.0001978038,0.0001501966,0.0001300561,0.0001752566,0.0001927667,0.0003832368,0.0003764634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707072,"about_ca_system_score_gemma":0.000222881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003383331,"about_ca_topic_score_gemma":0.001661164,"domain_scores_codex":[0.9999367,0.00001248981,0.000006473754,0.0000100027,0.00001300393,0.00002132232],"domain_scores_gemma":[0.999963,0.000004152513,0.00001148503,0.000002975693,0.00000836593,0.00001007684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001350777,0.000105425,0.0001797915,0.0001402634,0.00001633818,0.0001957324,0.00003498638,0.0006750694,0.9873981,0.0007194188,0.0001983994,0.01020129],"study_design_scores_gemma":[0.0002573429,0.004010919,0.003976658,0.00004058671,0.0001034403,0.0008802217,0.0000665663,0.002629159,0.9682099,0.0002722698,0.0195184,0.00003459611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751316,0.006015313,0.01088514,0.000317935,0.00005031399,0.0005021162,0.000709769,0.0001196035,0.006268115],"genre_scores_gemma":[0.9769778,0.006004483,0.01211724,0.0003233305,0.00002975053,0.0002133097,0.0007589379,0.00001741456,0.003557906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009800886,"threshold_uncertainty_score":0.003278673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0075907545780319,"score_gpt":0.2174638975426776,"score_spread":0.2098731429646457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}