{"id":"W2531981640","doi":"10.1021/acschemneuro.6b00163","title":"Synthesis of Gly-ψ[(<i>Z</i>)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research","keywords":"Peptidomimetic; Chemistry; Dipeptide; Isostere; Stereochemistry; Enkephalin; Amide; Hydrogen bond; Peptide bond; Thioamide; Peptide; Receptor; Biochemistry; Opioid; Organic chemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008866355,0.0002683178,0.0002499645,0.0001078585,0.00007907935,0.000143995,0.0001907157,0.0001792991,0.0007779855],"category_scores_gemma":[0.00009417597,0.0001027272,0.00019394,0.0001514273,0.00008487868,0.0001681554,0.0001565958,0.0002911554,0.0003705676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001866124,"about_ca_system_score_gemma":0.0002571641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003435013,"about_ca_topic_score_gemma":0.0004646555,"domain_scores_codex":[0.9999442,0.000006386091,0.000005757662,0.00001297483,0.00001619763,0.00001452586],"domain_scores_gemma":[0.999946,0.000004097572,0.00001444643,0.000004800664,0.000007685324,0.00002308234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006536864,0.00001601033,0.0000486907,0.00005658895,0.000004332943,0.00007551395,0.00001238031,0.0002469989,0.9962826,0.0001292331,0.00002305531,0.003039361],"study_design_scores_gemma":[0.00002818134,0.0007171391,0.0008715007,0.000005919468,0.00001638355,0.0003310311,0.00001470644,0.0008496517,0.9928086,0.00005108483,0.004295265,0.00001059569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973726,0.001878503,0.01880378,0.00007124154,0.00005774595,0.0001996699,0.0005942874,0.0001065625,0.004562205],"genre_scores_gemma":[0.9679446,0.001634127,0.02559512,0.00004560949,0.0000153298,0.00008853603,0.0006423589,0.00002692369,0.004007311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007779855,"threshold_uncertainty_score":0.002602637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265642687563491,"score_gpt":0.2515807546114036,"score_spread":0.2250164858550545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}