{"id":"W2531981640","doi":"10.1021/acschemneuro.6b00163","title":"Synthesis of Gly-ψ[(<i>Z</i>)CF═CH]-Phe, a Fluoroalkene Dipeptide Isostere, and Its Incorporation into a Leu-enkephalin Peptidomimetic","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research","keywords":"Peptidomimetic; Chemistry; Dipeptide; Isostere; Stereochemistry; Enkephalin; Amide; Hydrogen bond; Peptide bond; Thioamide; Peptide; Receptor; Biochemistry; Opioid; Organic chemistry; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853689,0.000325762,0.0004351021,0.0001230416,0.0001668069,0.00005875314,0.0007663388,0.0001009414,0.00001516307],"category_scores_gemma":[0.003773438,0.0002284239,0.0000979169,0.0005101284,0.0009886394,0.0005317958,0.0006127964,0.0001834506,0.00005235585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000295721,"about_ca_system_score_gemma":0.00005980355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001400539,"about_ca_topic_score_gemma":0.000001684781,"domain_scores_codex":[0.9971372,0.0001900421,0.0005629059,0.001167267,0.0004102126,0.0005323094],"domain_scores_gemma":[0.9978964,0.00100177,0.0003169158,0.0004500459,0.00007843339,0.0002564485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001251204,0.0001001995,0.0001647002,0.00004016927,9.308844e-7,0.00001893922,0.00003466268,0.00000154924,0.99193,0.00145486,0.00006387126,0.00606497],"study_design_scores_gemma":[0.0004310824,0.0002768948,0.0006950058,0.0000939186,0.00001406287,0.00007068299,0.000006679796,0.0001749493,0.9954154,0.001984594,0.0005581458,0.0002785106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980977,0.00002659144,0.00004041338,0.0004952708,0.0001558428,0.0002650529,0.00003420165,0.00008800322,0.0007969318],"genre_scores_gemma":[0.9978913,0.0001389908,0.000170877,0.001348663,0.0000781296,0.00003731643,4.94584e-7,0.00003661819,0.0002976004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005786459,"threshold_uncertainty_score":0.9314855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0265642687563491,"score_gpt":0.2515807546114036,"score_spread":0.2250164858550545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}