{"id":"W2532035602","doi":"10.1111/imm.12682","title":"Detrimental effect of systemic antimicrobial CD 4 + T‐cell reactivity on gut epithelial integrity","year":2016,"lang":"en","type":"article","venue":"Immunology","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Bern; AbbVie","keywords":"Immune system; Antimicrobial peptides; Immunology; Microbiology; Antigen; Intestinal epithelium; Antimicrobial; Biology; Innate immune system; T cell; Beta defensin; Systemic inflammation; Inflammation; Epithelium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005303418,0.000287733,0.0004582203,0.0001087245,0.00009837433,0.000009637582,0.0004077277,0.0003729981,0.000008709949],"category_scores_gemma":[0.001199521,0.0001970948,0.0001996747,0.0001183537,0.0004654031,0.00000756833,0.0004488945,0.0003158998,0.00009049451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009443038,"about_ca_system_score_gemma":0.000131293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001136978,"about_ca_topic_score_gemma":0.00001058806,"domain_scores_codex":[0.9978154,0.0006871008,0.0002975265,0.0005124857,0.0001634117,0.0005241237],"domain_scores_gemma":[0.9985594,0.0005099905,0.0001696745,0.0005865009,0.000117428,0.00005701266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004555112,0.0001812353,0.006721084,0.00006659701,0.0002454002,0.00001052912,0.0000653295,0.00000344195,0.9880427,0.00002181165,0.001273212,0.002913118],"study_design_scores_gemma":[0.002206328,0.002580159,0.004806341,0.00009521456,0.00002958243,0.0000404597,0.00006534503,0.000005129069,0.9869586,0.000007930431,0.003110586,0.00009437396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968097,0.000984851,0.0001036538,0.00008239865,0.0002437327,0.0004149277,0.0001056749,0.00002627159,0.001228786],"genre_scores_gemma":[0.9980345,0.0008218347,0.00006729391,0.00003746133,0.0001853835,0.00005148726,0.00002022426,0.00003101601,0.0007507826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002818744,"threshold_uncertainty_score":0.8037292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007684380917696848,"score_gpt":0.2550376061139914,"score_spread":0.2473532251962945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}