{"id":"W2532994364","doi":"10.1182/blood.v110.11.737.737","title":"Clinical Relevance of a Pharmacogenetic Approach Using Multiple Candidate Gene Polymorphisms To Predict Response and Resistance to Imatinib Mesylate Therapy in Chronic Myeloid Leukemia.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"","keywords":"Imatinib mesylate; Single-nucleotide polymorphism; Myeloid leukemia; Pharmacogenetics; Oncology; Medicine; Population; Internal medicine; Imatinib; Biology; Genotype; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001063729,0.0003485401,0.0003122762,0.0006395896,0.0001978596,0.0004077655,0.000217984,0.0005637804,0.001076252],"category_scores_gemma":[0.002904542,0.0001275691,0.0002928344,0.0004863388,0.0002466276,0.0002331165,0.0001925304,0.0004006966,0.0002457277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580965,"about_ca_system_score_gemma":0.0002325615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005877681,"about_ca_topic_score_gemma":0.0009191612,"domain_scores_codex":[0.9994123,0.0002604231,0.000058585,0.0001210017,0.0000990065,0.00004863996],"domain_scores_gemma":[0.9982893,0.0008427038,0.0005181864,0.0000506717,0.0001156135,0.0001836044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006269896,0.00004501157,0.9931626,0.00000752605,0.00005745029,0.0001503057,0.0000159383,0.0002940183,0.001263371,0.00001607681,0.00007647254,0.004284141],"study_design_scores_gemma":[0.00006339056,0.0005219258,0.9940111,0.000007945783,0.00009858682,0.0009445395,0.00004343489,0.003081996,0.0007953987,0.00007733735,0.0003466922,0.000007599981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988877,0.0002749988,0.0002057527,0.0001098568,0.000006535304,0.00001084913,0.000130919,0.000004865244,0.0003685863],"genre_scores_gemma":[0.9995714,0.00002285687,0.0002111927,0.00002775055,0.00001098303,0.00000716409,0.00008925609,0.000001020207,0.00005848423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001076252,"threshold_uncertainty_score":0.005625606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03150146730821448,"score_gpt":0.3282930907916318,"score_spread":0.2967916234834173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}