{"id":"W2532998048","doi":"10.1210/jc.2016-3211","title":"EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS","year":2016,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Aging; University of California","keywords":"Mitochondrial biogenesis; In vivo; Internal medicine; Endocrinology; Caloric theory; Oxidative stress; Skeletal muscle; Medicine; Body mass index; Mitochondrion; Chemistry; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000917758,0.0004654539,0.0009598374,0.0002003164,0.0003478334,0.0002894604,0.0002322309,0.0006604116,0.001397483],"category_scores_gemma":[0.0008109281,0.0001931616,0.0004284522,0.000183499,0.0002997666,0.0002012316,0.0002587277,0.000572268,0.0001587838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001816095,"about_ca_system_score_gemma":0.0002980354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009545048,"about_ca_topic_score_gemma":0.002117042,"domain_scores_codex":[0.9997557,0.00009778945,0.00002146052,0.00004934204,0.00002338767,0.00005243049],"domain_scores_gemma":[0.9994547,0.0001087872,0.00014925,0.0000596851,0.00004664369,0.000181032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7525479,0.02624425,0.06067854,0.001360419,0.002702282,0.0002417638,0.0002548873,0.0005890498,0.0640923,0.00005920316,0.0007343327,0.09049518],"study_design_scores_gemma":[0.03360713,0.3527393,0.6001998,0.000151054,0.002421252,0.0002210796,0.000163642,0.0005571202,0.00822654,0.00009812723,0.001571155,0.00004372851],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978042,0.00163739,0.0001418857,0.00005237229,0.00003163015,0.00007024821,0.00009028053,0.00001472019,0.0001572379],"genre_scores_gemma":[0.9977632,0.0006752062,0.0004724425,0.0001779808,0.00005189325,0.0001930979,0.000211554,0.000004958661,0.0004497371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397483,"threshold_uncertainty_score":0.004853666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275832275029121,"score_gpt":0.3092859109317084,"score_spread":0.2865275881814172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}