{"id":"W2532998048","doi":"10.1210/jc.2016-3211","title":"EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS","year":2016,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Aging; University of California","keywords":"Mitochondrial biogenesis; In vivo; Internal medicine; Endocrinology; Caloric theory; Oxidative stress; Skeletal muscle; Medicine; Body mass index; Mitochondrion; Chemistry; Biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00089139,0.0001505965,0.0006137544,0.000152145,0.00003449863,0.000002588088,0.0003452899,0.0002307876,0.000009069674],"category_scores_gemma":[0.001446542,0.00008894717,0.0002462745,0.00009710222,0.0002607926,0.000008645819,0.00008113337,0.0003436234,0.000003463119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009528336,"about_ca_system_score_gemma":0.0001399142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004998486,"about_ca_topic_score_gemma":0.00002743592,"domain_scores_codex":[0.9970242,0.0009351219,0.00131721,0.000188997,0.0002608341,0.0002735961],"domain_scores_gemma":[0.9976816,0.0006413291,0.001078741,0.0003360524,0.0001740559,0.00008821286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009250954,0.001624617,0.02121541,0.00008665369,0.0005732164,0.0000155184,0.0003932701,0.0005383033,0.9081414,0.001134061,0.00223301,0.05479361],"study_design_scores_gemma":[0.008908624,0.005574457,0.7844042,0.00006873812,0.0003853455,0.00002874606,0.00005293181,0.00000487022,0.1819133,0.002467855,0.01602759,0.000163388],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912618,0.002284665,0.002837358,0.0008727772,0.002486001,0.0002063082,0.000005787449,0.000003058871,0.00004223348],"genre_scores_gemma":[0.9881814,0.009842452,0.0003310503,0.0003473581,0.001239051,0.000003501164,0.00000140665,0.00001571852,0.0000381081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7631888,"threshold_uncertainty_score":0.362716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02275832275029121,"score_gpt":0.3092859109317084,"score_spread":0.2865275881814172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}