{"id":"W2533216488","doi":"10.1182/blood.v126.23.2719.2719","title":"A Randomized, Phase II Study with Biomarker Analysis of Panobinostat with or without Rituximab in Relapsed Diffuse Large B Cell Lymphoma","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Queen Elizabeth II Health Sciences Centre; Hôpital du Sacré-Cœur de Montréal; Simon Fraser University; Princess Margaret Cancer Centre; McGill University","funders":"","keywords":"Panobinostat; Rituximab; Medicine; Internal medicine; Oncology; Diffuse large B-cell lymphoma; Confidence interval; Lymphoma; Chemoimmunotherapy; Biology; Histone deacetylase; Histone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003583415,0.001769821,0.003184502,0.0005185352,0.0004685495,0.00118573,0.001069521,0.001747888,0.003694611],"category_scores_gemma":[0.002324774,0.0009589919,0.00134141,0.0007024285,0.001834282,0.001064691,0.0005067663,0.002925982,0.0008676899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001085417,"about_ca_system_score_gemma":0.001834832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007378078,"about_ca_topic_score_gemma":0.001277309,"domain_scores_codex":[0.9982432,0.001153144,0.00007416557,0.0002340665,0.0001140012,0.0001814979],"domain_scores_gemma":[0.9978781,0.0005301413,0.0004099204,0.0002511379,0.0001331831,0.0007975174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9636573,0.01764473,0.002147644,0.0002080584,0.000622371,0.00006089626,0.00004887882,0.0003775948,0.004434548,0.00007800348,0.0004284565,0.01029149],"study_design_scores_gemma":[0.8483671,0.1479556,0.00222129,0.000008733304,0.0002166782,0.00004791546,0.00001616481,0.0003521904,0.0004180359,0.00006566427,0.0003212299,0.000009311212],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930124,0.001360804,0.0005116829,0.0003423372,0.0002252637,0.003349852,0.0004431772,0.00005612644,0.0006984438],"genre_scores_gemma":[0.9882336,0.001101868,0.001730619,0.0008418477,0.0003826772,0.005305025,0.0011334,0.00002272117,0.001248253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003694611,"threshold_uncertainty_score":0.01895112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723498590964666,"score_gpt":0.2973524630710236,"score_spread":0.2801174771613769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}