{"id":"W2533262657","doi":"10.1158/1078-0432.ccr-16-1241","title":"An Open-Label, Dose–Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University College of the North","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Adverse effect; Melanoma; Internal medicine; Cancer; Oncology; Monoclonal antibody; Refractory (planetary science); Maximum tolerated dose; Gastroenterology; Antibody; Pharmacology; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001788872,0.001857431,0.002058363,0.0005378154,0.0004717397,0.0008811916,0.001037517,0.001194141,0.002582692],"category_scores_gemma":[0.0008303263,0.0005753335,0.001049292,0.0003885653,0.001004643,0.0008991332,0.0003275687,0.003783299,0.000847958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098835,"about_ca_system_score_gemma":0.001620702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006320113,"about_ca_topic_score_gemma":0.00202063,"domain_scores_codex":[0.9995223,0.0002045029,0.00002430957,0.00007615807,0.00006524604,0.0001073665],"domain_scores_gemma":[0.9993457,0.0001035273,0.000133337,0.00005977053,0.00005000043,0.0003075771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5152577,0.1783021,0.01072922,0.001297548,0.001455288,0.0006036994,0.0007045292,0.004514309,0.1086891,0.0004913816,0.007279607,0.1706756],"study_design_scores_gemma":[0.3945755,0.5837873,0.01025617,0.0000313928,0.0002484641,0.0003116917,0.00005522708,0.00225309,0.005388599,0.0001764481,0.00288678,0.00002925913],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933136,0.001211384,0.0006000968,0.000307472,0.0001182151,0.002419524,0.0005933917,0.0001117767,0.001324504],"genre_scores_gemma":[0.9897558,0.0009235061,0.00214359,0.000798618,0.0002116012,0.002527215,0.001639711,0.000035025,0.001964995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002582692,"threshold_uncertainty_score":0.009460568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1974395985532057,"score_gpt":0.5574835291935856,"score_spread":0.3600439306403799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}