{"id":"W2533262657","doi":"10.1158/1078-0432.ccr-16-1241","title":"An Open-Label, Dose–Escalation Phase I Study of Anti-TYRP1 Monoclonal Antibody IMC-20D7S for Patients with Relapsed or Refractory Melanoma","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University College of the North","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Adverse effect; Melanoma; Internal medicine; Cancer; Oncology; Monoclonal antibody; Refractory (planetary science); Maximum tolerated dose; Gastroenterology; Antibody; Pharmacology; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001565715,0.0001301114,0.0002766979,0.00006385799,0.0001410488,0.00003896626,0.0004728218,0.0001675681,0.0001046867],"category_scores_gemma":[0.0004699539,0.00007765854,0.00002972094,0.0001506534,0.0001879774,0.00002954714,0.0001533501,0.0001410108,0.000004006156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003680398,"about_ca_system_score_gemma":0.0003333532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009058188,"about_ca_topic_score_gemma":0.0001281252,"domain_scores_codex":[0.9975738,0.0005324505,0.0005443539,0.0006006556,0.0004486563,0.0003000676],"domain_scores_gemma":[0.9981381,0.0002967564,0.0001939618,0.0005111662,0.0006925978,0.0001674158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03319148,0.01769065,0.4757734,0.00004984171,0.0002326237,0.000005872338,0.0001225254,0.000003007372,0.3975588,0.00003082159,0.002838627,0.07250234],"study_design_scores_gemma":[0.1305496,0.2053177,0.6012257,0.0002094641,0.0001058831,0.000001380096,0.0004420567,0.0002306453,0.05086381,0.0001248613,0.010292,0.0006368331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972639,0.00004857083,0.0004937639,0.00008583326,0.0001679473,0.001728434,0.0001409998,0.000006052416,0.00006450259],"genre_scores_gemma":[0.9980232,0.000202856,0.0004891465,0.00004054157,0.0002630732,0.0002263503,0.000311501,0.00003170889,0.000411605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3466949,"threshold_uncertainty_score":0.3166823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1974395985532057,"score_gpt":0.5574835291935856,"score_spread":0.3600439306403799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}