{"id":"W2533302525","doi":"10.1021/acs.chemrestox.6b00323","title":"Understanding the Mutagenicity of O-Linked and C-Linked Guanine DNA Adducts: A Combined Experimental and Computational Approach","year":2016,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Adduct; Chemistry; Nucleobase; Guanine; Deoxyguanosine; Stereochemistry; DNA; Moiety; DNA adduct; Nuclear magnetic resonance spectroscopy; DNA damage; Nucleotide; Mutagenesis; Biochemistry; Mutation; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004652508,0.0001034441,0.0001604585,0.00003062352,0.00005994159,0.00001005371,0.0001905971,0.0002087528,0.00002280417],"category_scores_gemma":[0.0002914637,0.00006819875,0.00002783992,0.0001006064,0.001272387,0.000004360885,0.0003748829,0.000155688,7.613265e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008037546,"about_ca_system_score_gemma":0.00007173917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003412736,"about_ca_topic_score_gemma":0.00000103228,"domain_scores_codex":[0.9988708,0.0001141177,0.0002011806,0.0003372347,0.0001794148,0.0002971805],"domain_scores_gemma":[0.9994087,0.000219221,0.00004300764,0.0001746872,0.00005357989,0.0001007826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003018234,0.0001486681,0.001472972,0.00002708856,0.00002547044,0.000002803068,0.00006396299,0.000001321637,0.9955975,0.001851775,0.0002975965,0.0002090275],"study_design_scores_gemma":[0.002430358,0.0003275392,0.001388294,0.00002212082,0.000004588069,0.00004130147,0.0006281683,0.000385072,0.9892665,0.005235136,0.0001442405,0.000126654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969115,0.0003440952,0.0006639216,0.0008215148,0.00001723478,0.0001725782,0.00001474728,0.000004771552,0.001049583],"genre_scores_gemma":[0.9992818,0.00005233304,0.0004301295,0.00006350522,0.00005131149,0.00002990478,0.00002309385,0.000009410228,0.00005854878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006330964,"threshold_uncertainty_score":0.4688161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1173006848226345,"score_gpt":0.3524410264553538,"score_spread":0.2351403416327193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}