{"id":"W2533302525","doi":"10.1021/acs.chemrestox.6b00323","title":"Understanding the Mutagenicity of O-Linked and C-Linked Guanine DNA Adducts: A Combined Experimental and Computational Approach","year":2016,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Adduct; Chemistry; Nucleobase; Guanine; Deoxyguanosine; Stereochemistry; DNA; Moiety; DNA adduct; Nuclear magnetic resonance spectroscopy; DNA damage; Nucleotide; Mutagenesis; Biochemistry; Mutation; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008292766,0.001215027,0.001726293,0.00121236,0.0005721778,0.001203562,0.001631357,0.002377313,0.002330408],"category_scores_gemma":[0.001807335,0.0006517364,0.001502327,0.0009727463,0.0007776843,0.001333814,0.0007971666,0.001384636,0.0003492371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007782358,"about_ca_system_score_gemma":0.001834342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007142299,"about_ca_topic_score_gemma":0.005444212,"domain_scores_codex":[0.9997967,0.00005862855,0.00001189322,0.0000360639,0.00006313105,0.00003352992],"domain_scores_gemma":[0.9988793,0.0007963003,0.00007524146,0.00007796167,0.0001270536,0.00004411085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005414658,0.00009991148,0.001194702,0.0003518971,0.00008308879,0.0000955501,0.00002531113,0.986402,0.002251707,0.005087146,0.0003424023,0.004012126],"study_design_scores_gemma":[0.00002377665,0.00004808135,0.0002794768,0.00001893939,0.00003141449,0.00001786738,0.00002312885,0.9942273,0.0006600521,0.004074801,0.0005851173,0.00001002924],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7011052,0.01121897,0.2408219,0.002874499,0.0003886049,0.0003926165,0.00515444,0.001289303,0.03675434],"genre_scores_gemma":[0.9084554,0.005419845,0.07797462,0.0005199143,0.000179629,0.0009737638,0.003501933,0.0002298439,0.002745044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007142299,"threshold_uncertainty_score":0.01420146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1173006848226345,"score_gpt":0.3524410264553538,"score_spread":0.2351403416327193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}