{"id":"W2533517250","doi":"10.1021/acs.joc.6b02312","title":"Sesterterpenoids Isolated from the Sponge <i>Phorbas</i> sp. Activate Latent HIV-1 Provirus Expression","year":2016,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; Simon Fraser University; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; International Development Research Centre","keywords":"Sponge; Chemistry; Provirus; Stereochemistry; Terpenoid; Biochemistry; Gene; Biology; Botany; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636197,0.0001892095,0.0001722895,0.000007006067,0.0001040162,0.00002443829,0.0006662243,0.0001392848,0.0005266723],"category_scores_gemma":[0.0001637455,0.0000773773,0.0001056066,0.00007372146,0.00008311289,0.0000122668,0.0002847628,0.000278493,0.00001596718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002886641,"about_ca_system_score_gemma":0.00009340202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008091556,"about_ca_topic_score_gemma":0.00000264758,"domain_scores_codex":[0.9989815,0.00008274642,0.0003222433,0.000185286,0.0002129364,0.0002152978],"domain_scores_gemma":[0.9988054,0.00006660631,0.0003617569,0.0005478796,0.000134022,0.00008435907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006132498,0.0000350928,0.0009200679,0.000008200377,0.00007223742,0.000007153839,0.00004155276,7.310991e-7,0.9877812,1.375136e-7,0.00794931,0.002571062],"study_design_scores_gemma":[0.0007600063,0.00009019326,0.001850612,0.00008012643,0.00005802931,0.0002185321,0.00003472033,0.000001979339,0.9765949,0.00003433708,0.02014021,0.0001364055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937684,0.001333602,0.0002417824,0.004192429,0.0001825145,0.00009203619,0.00002162857,0.0000071748,0.0001604279],"genre_scores_gemma":[0.9949575,0.0009980614,0.00004629254,0.0003044592,0.001065498,8.648993e-7,0.00001207337,0.00002800959,0.002587245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0121909,"threshold_uncertainty_score":0.5766692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006033734380490983,"score_gpt":0.2026942226721255,"score_spread":0.1966604882916345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}