{"id":"W2533712430","doi":"10.1017/cjn.2016.364","title":"PS2 - 153 Dianhydrogalactitol (VAL-083) Treatment Causes Irreparable DNA Double-Strand Breaks, S/G2 Phase Cell-Cycle Arrest and Cell Death in Cancer Cells","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto","funders":"","keywords":"LNCaP; Cisplatin; Cell cycle; Cancer research; Cell cycle checkpoint; Temozolomide; DNA repair; DNA damage; Chemistry; Cancer cell; Biology; Molecular biology; DNA; Glioma; Cancer; Cell; Biochemistry; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003969613,0.0003822817,0.0002318132,0.0001231149,0.0001366017,0.0001426089,0.0001330979,0.0002197658,0.001586276],"category_scores_gemma":[0.00004036608,0.0001051622,0.0001941787,0.0001855535,0.0001538819,0.00009160853,0.0001087474,0.0004339348,0.0004021633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205544,"about_ca_system_score_gemma":0.0002118963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001314865,"about_ca_topic_score_gemma":0.001423022,"domain_scores_codex":[0.9999276,0.000009420015,0.000007226752,0.00001660869,0.0000209814,0.00001811815],"domain_scores_gemma":[0.9999624,0.00000689916,0.000009994659,0.000006058588,0.000004020849,0.00001053323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001146725,0.0000221545,0.00008406321,0.00002196648,0.000004224213,0.00004000852,0.00001062486,0.0000302866,0.9989717,0.00002367318,0.000043341,0.0006333804],"study_design_scores_gemma":[0.00000947539,0.0004643936,0.001758057,0.000001434708,0.000005394931,0.0001392044,0.00001119511,0.0001180467,0.9963712,0.00001065819,0.001109279,0.00000170566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943368,0.001592507,0.0008571459,0.0000643274,0.00003193762,0.00003782876,0.0007554482,0.0001310839,0.002192984],"genre_scores_gemma":[0.9940993,0.0009122427,0.0007076109,0.00005384799,0.000005287256,0.00003901518,0.001292857,0.00001779414,0.002871964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001586276,"threshold_uncertainty_score":0.005306661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499653720551163,"score_gpt":0.2791938411780926,"score_spread":0.254197303972581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}