{"id":"W2533983246","doi":"10.1016/j.jalz.2016.06.1698","title":"P3‐040: Design, Synthesis, and Evaluation of Novel Phenoselenazine (PSZ) Based Tricyclic Compounds as Potential Agents to Treat Alzheimer’s Disease","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Tricyclic; Chemistry; Antioxidant; Thioflavin; Selenium; Amyloid (mycology); Amyloid beta; Fluorescence; Alzheimer's disease; Combinatorial chemistry; Biophysics; Pharmacology; Stereochemistry; Biochemistry; Disease; Peptide; Organic chemistry; Medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007170296,0.0002309416,0.0001402662,0.0001233677,0.00007671379,0.0001290581,0.0002354317,0.0001431645,0.001019967],"category_scores_gemma":[0.0000635774,0.00007633972,0.0001051771,0.0001470245,0.0001011537,0.0001181261,0.0001056121,0.0001697183,0.0002457235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458502,"about_ca_system_score_gemma":0.0002029601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005113539,"about_ca_topic_score_gemma":0.0008171211,"domain_scores_codex":[0.9999751,0.000004357089,0.000002239678,0.000005711975,0.000006899313,0.000005623273],"domain_scores_gemma":[0.9999795,0.000001637143,0.000005561815,0.000001714659,0.000004883608,0.000006647194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002234792,0.0001095798,0.000283812,0.0002288037,0.00001540885,0.0001859548,0.00002727297,0.00082299,0.9726712,0.0003072157,0.0002021594,0.02492219],"study_design_scores_gemma":[0.0001501285,0.004156222,0.003428409,0.00001801291,0.00005293853,0.0005747961,0.00002328131,0.002808689,0.9801153,0.000103805,0.008557048,0.00001140714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863452,0.003459441,0.005313389,0.0001063544,0.00001900674,0.0001660711,0.0003996686,0.00007515333,0.004115725],"genre_scores_gemma":[0.9845172,0.003488376,0.007995632,0.00008054773,0.000007642913,0.00007918099,0.00048384,0.000009688981,0.0033379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001019967,"threshold_uncertainty_score":0.003412068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.156729918361177,"score_gpt":0.4016684929516136,"score_spread":0.2449385745904366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}