{"id":"W2533988460","doi":"10.1038/gt.2016.70","title":"Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy","year":2016,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Oncolytics Biotech; National Institute for Health and Care Research; National Cancer Institute; National Institutes of Health; Cancer Research UK; University of Minnesota; Rosetrees Trust; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Vesicular stomatitis virus; Blockade; Immune system; Priming (agriculture); Biology; CD8; Immunology; Combination therapy; Cancer research; Virology; Antigen; Virus; Melanoma; Immune checkpoint; Immunotherapy; Receptor; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005396209,0.000347102,0.0003071229,0.0001672973,0.0001162742,0.00003996603,0.000375733,0.000177323,0.00005539732],"category_scores_gemma":[0.00001596946,0.0002319875,0.0001009913,0.0002745012,0.0001796412,0.00001864071,0.00005938703,0.0001266248,0.00002343109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001012906,"about_ca_system_score_gemma":0.0003815111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000766767,"about_ca_topic_score_gemma":0.0001277244,"domain_scores_codex":[0.997888,0.0002518515,0.0003401415,0.0006124976,0.0003239906,0.0005834783],"domain_scores_gemma":[0.9989276,0.00002721628,0.0001637234,0.0006115265,0.0001521333,0.0001178242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005354673,0.0003031743,0.002674554,0.000003825277,0.0001168794,0.000009080034,0.00008845194,0.00008256414,0.9712854,0.000002946512,0.00001524528,0.02006317],"study_design_scores_gemma":[0.007126344,0.005235745,0.005843532,0.00003126941,0.000004730918,0.0000229676,0.00002347534,0.000104769,0.9797663,0.00009280052,0.0013616,0.0003864279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954523,0.002699675,0.0005241435,0.0003241612,0.00007930537,0.0008084041,0.00001389655,0.00003374503,0.00006431714],"genre_scores_gemma":[0.9953463,0.003257733,0.0003477967,0.0003927626,0.0002143794,0.00007742703,0.00001915363,0.00009451042,0.0002499062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01967675,"threshold_uncertainty_score":0.9460174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03414254946724767,"score_gpt":0.3196210101657175,"score_spread":0.2854784606984698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}