{"id":"W2533988460","doi":"10.1038/gt.2016.70","title":"Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy","year":2016,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"Oncolytics Biotech; National Institute for Health and Care Research; National Cancer Institute; National Institutes of Health; Cancer Research UK; University of Minnesota; Rosetrees Trust; Mayo Foundation for Medical Education and Research","keywords":"Oncolytic virus; Vesicular stomatitis virus; Blockade; Immune system; Priming (agriculture); Biology; CD8; Immunology; Combination therapy; Cancer research; Virology; Antigen; Virus; Melanoma; Immune checkpoint; Immunotherapy; Receptor; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002500811,0.000587011,0.0008202982,0.0003733791,0.0001762714,0.0007505282,0.0004494643,0.0005403336,0.002234704],"category_scores_gemma":[0.0003133714,0.0002705542,0.0004045719,0.0002618591,0.0003402283,0.0006530589,0.0002894455,0.00164012,0.000484729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004471852,"about_ca_system_score_gemma":0.0005952757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007485938,"about_ca_topic_score_gemma":0.001009663,"domain_scores_codex":[0.9998147,0.00002334635,0.000009004408,0.00004938808,0.00004415216,0.00005944814],"domain_scores_gemma":[0.9998786,0.00003232435,0.00002278038,0.0000258478,0.00001009048,0.00003030294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00227551,0.001065757,0.0004357935,0.0001000182,0.00004297085,0.00004337685,0.00004469254,0.001189757,0.9613103,0.0007905519,0.0004691255,0.03223201],"study_design_scores_gemma":[0.0003013365,0.003469202,0.002063864,0.00001317441,0.0001239344,0.0002779997,0.00002221906,0.003407862,0.9864396,0.0002648516,0.003602811,0.00001300759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817482,0.004990692,0.009119369,0.0002433188,0.0003057743,0.0001560285,0.0002377175,0.0005620411,0.002636825],"genre_scores_gemma":[0.9913083,0.001381428,0.004101619,0.00005613248,0.0000564208,0.00006140338,0.0001913346,0.00007331704,0.002770081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002234704,"threshold_uncertainty_score":0.007475793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03414254946724767,"score_gpt":0.3196210101657175,"score_spread":0.2854784606984698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}