{"id":"W2534121364","doi":"10.1200/jco.2006.24.18_suppl.13015","title":"A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first line treatment in hormone refractory prostate cancer (HRPC)","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Metal-Catalyzed Oxygenation Mechanisms","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Juravinski Cancer Centre; BC Cancer Agency","funders":"","keywords":"Docetaxel; Medicine; Neutropenia; Tolerability; Prostate cancer; Internal medicine; Chemotherapy; Oncology; Ribonucleotide reductase; Pharmacology; Cabazitaxel; Cancer; Gastroenterology; Adverse effect; Androgen deprivation therapy; Biology; Protein subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060085,0.00137644,0.001847674,0.0005622923,0.0004091222,0.0007658522,0.0009239308,0.001078798,0.003437586],"category_scores_gemma":[0.0005263878,0.0007051118,0.0008363394,0.0004814044,0.0009355891,0.0005736713,0.0002673658,0.002293624,0.000721098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001003902,"about_ca_system_score_gemma":0.002465026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002171426,"about_ca_topic_score_gemma":0.004633994,"domain_scores_codex":[0.9996699,0.0001289847,0.00001761028,0.00007267711,0.00003921806,0.00007155268],"domain_scores_gemma":[0.9994758,0.00006947558,0.00007853851,0.00004323639,0.00003716448,0.0002957846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5014876,0.1886208,0.006969908,0.001464554,0.001326052,0.000545438,0.0004978661,0.004577934,0.1600102,0.0004589889,0.00364277,0.1303981],"study_design_scores_gemma":[0.2843544,0.7010327,0.006750823,0.0000260924,0.000266751,0.0002880328,0.00004337627,0.00102319,0.004472106,0.00006824526,0.001652891,0.00002133037],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936562,0.0009454646,0.0004206223,0.0001783435,0.0001177632,0.003170453,0.0005265144,0.00007277761,0.000911907],"genre_scores_gemma":[0.9871964,0.00167774,0.002450522,0.0005206931,0.0002112735,0.003555554,0.001662153,0.00002682509,0.002698829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003437586,"threshold_uncertainty_score":0.01149982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0692760631176686,"score_gpt":0.4176388006762158,"score_spread":0.3483627375585472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}