{"id":"W2534178318","doi":"10.1016/j.it.2016.09.008","title":"T Cell Genesis: In Vitro Veritas Est ?","year":2016,"lang":"en","type":"review","venue":"Trends in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Immunotherapy; Cancer immunotherapy; Immune system; Immunology; Chimeric antigen receptor; Haematopoiesis; Biology; Progenitor cell; Induced pluripotent stem cell; Antigen; Cell therapy; Stem cell; Cancer research; Antigen-presenting cell; T cell; Cell biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001814856,0.001066862,0.002139639,0.0008440921,0.0003405718,0.002569591,0.001524889,0.002390038,0.005076028],"category_scores_gemma":[0.001424346,0.0003687277,0.000641616,0.0007796004,0.001319139,0.00291609,0.001066789,0.00387605,0.003490937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007988079,"about_ca_system_score_gemma":0.001534912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005587267,"about_ca_topic_score_gemma":0.0009606933,"domain_scores_codex":[0.9995335,0.0001362562,0.00004908381,0.00007777902,0.0001320528,0.00007138589],"domain_scores_gemma":[0.9992918,0.0003755173,0.00007357199,0.0000397077,0.0001590301,0.00006031257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002695984,0.0001524278,0.0004228127,0.01188122,0.0001135865,0.0004042225,0.0001216247,0.0004566845,0.005976446,0.01888017,0.05567155,0.9056497],"study_design_scores_gemma":[0.00004121793,0.0001555011,0.0003139469,0.00254552,0.0001156466,0.001020527,0.0001256877,0.0001325691,0.001906911,0.005051925,0.9885707,0.00001974032],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001551852,0.9966414,0.0003039139,0.00104813,0.0007688084,0.00000420858,0.00001638776,0.000006843915,0.001055117],"genre_scores_gemma":[0.001929337,0.9945202,0.0004176687,0.0009565917,0.001088803,0.00001540086,0.0000452157,0.000003405859,0.001023443],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005076028,"threshold_uncertainty_score":0.01698101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06661487666658868,"score_gpt":0.3849451041923543,"score_spread":0.3183302275257656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}