{"id":"W2534178318","doi":"10.1016/j.it.2016.09.008","title":"T Cell Genesis: In Vitro Veritas Est ?","year":2016,"lang":"en","type":"review","venue":"Trends in Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Immunotherapy; Cancer immunotherapy; Immune system; Immunology; Chimeric antigen receptor; Haematopoiesis; Biology; Progenitor cell; Induced pluripotent stem cell; Antigen; Cell therapy; Stem cell; Cancer research; Antigen-presenting cell; T cell; Cell biology; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004446866,0.0004817056,0.002572697,0.002349446,0.000021737,0.00001042191,0.0004902515,0.000876996,0.008363379],"category_scores_gemma":[0.0000563741,0.0003606788,0.0004567833,0.001092261,0.0002481994,0.00003719078,0.0002251932,0.001179507,0.001003501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007821555,"about_ca_system_score_gemma":0.0004319773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002433959,"about_ca_topic_score_gemma":0.00004491082,"domain_scores_codex":[0.9969382,0.0004922849,0.0008477672,0.0006560981,0.0002243525,0.00084134],"domain_scores_gemma":[0.9982944,0.0003367134,0.0001746836,0.001082553,0.00003459743,0.00007707648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003050129,0.0002293046,0.00001079696,0.001702544,0.0001587006,0.0004877885,0.00005998035,1.577915e-8,0.002393074,0.00002569078,0.0004394459,0.9941877],"study_design_scores_gemma":[0.002145662,0.0002431224,0.00007515456,0.003699882,0.0001267126,0.0002577881,0.00001894786,4.569541e-7,0.0002563365,0.0000206444,0.9928598,0.0002954315],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000155657,0.966774,8.932884e-7,0.0001072011,0.0004190543,0.0003894815,0.00003690517,0.00004741619,0.03206943],"genre_scores_gemma":[0.00009226828,0.9673603,0.00008735664,0.00002925603,0.0001586681,0.0002937444,0.000222819,0.0001162826,0.03163929],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9938922,"threshold_uncertainty_score":0.9998845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06661487666658868,"score_gpt":0.3849451041923543,"score_spread":0.3183302275257656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}