{"id":"W2534359235","doi":"10.1016/j.phrs.2016.10.019","title":"ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo","year":2016,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Melanoma; In vivo; Cell growth; Pharmacology; Apoptosis; Protein kinase B; Chemistry; Cancer research; In vitro; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001735991,0.0002359244,0.000470894,0.000417605,0.0003104145,0.00001823382,0.0003848156,0.000279356,0.002309354],"category_scores_gemma":[0.0001306947,0.0001605048,0.00006181713,0.0003055545,0.0008237094,0.0001040769,0.0005447656,0.0005286112,0.0001427461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466082,"about_ca_system_score_gemma":0.0001590228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001375127,"about_ca_topic_score_gemma":0.00005292458,"domain_scores_codex":[0.9971595,0.00059837,0.0006250084,0.0005618565,0.0001980135,0.0008572193],"domain_scores_gemma":[0.9986017,0.0008056092,0.0001342414,0.0001665399,0.00017935,0.0001125484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001678673,0.0004484065,0.005928231,0.00006409485,0.00009766532,0.00001527508,0.0005055176,4.993815e-7,0.9853674,0.0004487866,0.0006996368,0.006256639],"study_design_scores_gemma":[0.002711572,0.0001967899,0.007568168,0.0001032207,0.00001441561,0.000007609148,0.0001363686,0.000001545515,0.9735852,0.00005721917,0.01540376,0.0002140851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961227,0.001273576,0.000008129364,0.0002806494,0.0001097872,0.0004928637,0.00002957889,0.00003135351,0.001651331],"genre_scores_gemma":[0.9968054,0.0004367243,0.00008062844,0.00003423172,0.00003412171,0.00007406002,0.000006741058,0.00001944241,0.002508636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01470412,"threshold_uncertainty_score":0.9986027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05685123120633469,"score_gpt":0.3285723619932496,"score_spread":0.271721130786915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}