{"id":"W2534370894","doi":"10.1016/j.jalz.2016.06.1705","title":"P3‐047: The Amyloid‐Beta (Aβ) Oligomer‐Specific CYCLIC‐SER‐ASN‐LYS (CSNK) Tripeptide is Highly Immunogenic and Induces Sustained Levels of ANTI‐CSNK Antibodies of the IGG1 Subclass","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Isotype; Epitope; Antibody; Subclass; Adjuvant; Chemistry; Molecular biology; Immune system; Immunogenicity; Tripeptide; Immunogen; Monoclonal antibody; Immunology; Biology; Biochemistry; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001486398,0.0005179205,0.0002946932,0.0002839854,0.000161724,0.0002367921,0.0002457776,0.0004411045,0.002041931],"category_scores_gemma":[0.0001100505,0.0001398202,0.0003009553,0.0001548717,0.0003251518,0.0002535987,0.0001995142,0.0009717493,0.0008220448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623539,"about_ca_system_score_gemma":0.0002179701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004496295,"about_ca_topic_score_gemma":0.0004225794,"domain_scores_codex":[0.9998267,0.00002055405,0.00001322282,0.00004716157,0.00004049122,0.00005186755],"domain_scores_gemma":[0.9998473,0.00001764564,0.0000396729,0.00001927097,0.00001852403,0.00005755679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004875412,0.0003250872,0.0004551957,0.00003366299,0.000006683466,0.0001069851,0.00001421386,0.0000419967,0.9969165,0.00005261056,0.00007404922,0.00148549],"study_design_scores_gemma":[0.0001193885,0.006609786,0.01091732,0.00001276438,0.00003046558,0.001053591,0.00003832904,0.0004506462,0.9777394,0.00007969396,0.00294087,0.000007853534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979443,0.0001808176,0.0005875253,0.00005276137,0.00001760519,0.00003739305,0.0003500519,0.00003614462,0.0007933468],"genre_scores_gemma":[0.9908929,0.0004149314,0.001790385,0.0001343431,0.00002782038,0.0001104734,0.001802788,0.00003397509,0.004792266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041931,"threshold_uncertainty_score":0.006830931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03649259773018183,"score_gpt":0.2924880757783529,"score_spread":0.2559954780481711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}