{"id":"W2534457406","doi":"10.1038/srep35539","title":"Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Vlaamse regering; KU Leuven; Fonds Wetenschappelijk Onderzoek","keywords":"Sex hormone-binding globulin; Internal medicine; Endocrinology; Testosterone (patch); Androgen; Hormone; Sex steroid; Biology; In vivo; Steroid hormone; Sex hormone receptor; Estrogen; Seminal vesicle; Globulin; Steroid; Estrogen receptor; Medicine; Prostate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000938711,0.0005094465,0.0003466678,0.000373487,0.0001815588,0.0005321809,0.0003270585,0.0002998578,0.0008347736],"category_scores_gemma":[0.0004931878,0.0001901305,0.0003096215,0.000147189,0.001101623,0.0005372505,0.0003117375,0.0006134941,0.0001768871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004095064,"about_ca_system_score_gemma":0.000308443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009468271,"about_ca_topic_score_gemma":0.0008204839,"domain_scores_codex":[0.9996964,0.0001203545,0.00001404952,0.0000614317,0.00006794203,0.00003986381],"domain_scores_gemma":[0.9993964,0.0002690527,0.00006600895,0.0001290319,0.00007097853,0.00006843622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00082273,0.00005419974,0.00132763,0.0000740966,0.00003036259,0.00007446099,0.0001006406,0.0001285394,0.991875,0.001081431,0.00005178161,0.004379184],"study_design_scores_gemma":[0.0000562165,0.001167035,0.02948515,0.00001938068,0.0000632958,0.0003003618,0.0001107715,0.001248526,0.9630568,0.001251224,0.003219466,0.0000217735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652203,0.01442107,0.01740233,0.0003743387,0.0001252966,0.00003550007,0.0002690578,0.00009031518,0.002061869],"genre_scores_gemma":[0.9915167,0.003023286,0.003360063,0.0001593359,0.00005916489,0.00003734121,0.0002206221,0.00004586919,0.001577587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009468271,"threshold_uncertainty_score":0.004964471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578569310983246,"score_gpt":0.248044431723381,"score_spread":0.2222587386135485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}