{"id":"W2534754670","doi":"10.1093/hmg/ddw361","title":"Variegated yet non-random rod and cone photoreceptor disease patterns in<i>RPGR-ORF15</i>-associated retinal degeneration","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Eye Institute; Applied Genetic Technologies Corporation; Macula Vision Research Foundation","keywords":"Retinitis pigmentosa; Biology; Retinal degeneration; Retina; Rhodopsin; Retinal; Opsin; Degeneration (medical); Macular degeneration; Ophthalmology; Pathology; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822282,0.0002659324,0.0002027405,0.00007874105,0.0001048307,0.00005131354,0.0001612456,0.0001686804,0.00006562062],"category_scores_gemma":[0.0001184445,0.0002330432,0.00007461487,0.00009495763,0.0001102389,0.000005976436,0.0001196579,0.00007313039,0.000009271729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002946002,"about_ca_system_score_gemma":0.0000908906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002029713,"about_ca_topic_score_gemma":0.0001339912,"domain_scores_codex":[0.9984493,0.0001240194,0.0003346466,0.0005178261,0.000217045,0.0003572004],"domain_scores_gemma":[0.9992713,0.00001352223,0.0001142082,0.0002989525,0.0001099978,0.0001919859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001832924,0.00009296757,0.1023738,0.00001652726,0.0000421615,0.00002547002,0.00005114794,0.00002013649,0.8960416,0.00004604346,0.0005042221,0.0006026987],"study_design_scores_gemma":[0.007848218,0.0005087912,0.5465127,0.0001611876,0.00009239554,0.000005918388,0.00004456683,0.0001990487,0.4396906,0.0006549507,0.003346798,0.0009348997],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939469,0.0006975314,0.00441728,0.0001403252,0.0001007346,0.0003666024,0.00004188352,0.00001700056,0.0002717806],"genre_scores_gemma":[0.997815,0.0005251641,0.0002888682,0.0003085937,0.000050986,0.00005179565,0.000496629,0.00004630374,0.0004166815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.456351,"threshold_uncertainty_score":0.9503227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005991737127223584,"score_gpt":0.222916546295527,"score_spread":0.2169248091683034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}