{"id":"W2534849842","doi":"10.1016/j.chembiol.2016.09.012","title":"A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus","year":2016,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Vanderbilt Institute of Chemical Biology, School of Medicine, Vanderbilt University; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of Arkansas; School of Medicine, Indiana University; U.S. Department of Agriculture; Rutgers, The State University of New Jersey; University of Arkansas for Medical Sciences; York University; Vanderbilt University; Douglas Foundation; National Cancer Institute; National Institutes of Health; Vanderbilt-Ingram Cancer Center","keywords":"Virulence; Staphylococcus aureus; Small molecule; Biology; Virulence factor; Aconitase; Regulator; Gene cluster; Microbiology; Drug discovery; Enzyme; Sulfur metabolism; Bacteria; Gene; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535778,0.000273883,0.0003191071,0.0001868168,0.0002042078,0.0002527312,0.0003831709,0.000353797,0.001402682],"category_scores_gemma":[0.0001292563,0.0001705171,0.0002052361,0.00009712688,0.0002094912,0.0001028515,0.0001431411,0.0005359169,0.0002278838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003086675,"about_ca_system_score_gemma":0.0003233542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001129564,"about_ca_topic_score_gemma":0.002918696,"domain_scores_codex":[0.9999354,0.000008644656,0.00000425267,0.00001004319,0.00001988069,0.00002167727],"domain_scores_gemma":[0.999948,0.00001662235,0.00001071513,0.000005052219,0.000005285206,0.00001433501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008382915,0.000221067,0.000264856,0.00005818308,0.00002147658,0.0001515356,0.00002068049,0.0003552159,0.9923391,0.0004318537,0.0003055456,0.004992119],"study_design_scores_gemma":[0.0003219209,0.002008317,0.003064773,0.00001165526,0.00004483276,0.0002870373,0.00002742762,0.003687267,0.9863552,0.000165444,0.004013256,0.00001291597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908717,0.002129358,0.002908597,0.0004025182,0.0001204798,0.00007174109,0.0002098734,0.0001854054,0.003100217],"genre_scores_gemma":[0.9953047,0.001136693,0.001387587,0.0001327014,0.00002260947,0.00002569817,0.0002220114,0.00001600946,0.001752027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402682,"threshold_uncertainty_score":0.004692435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01387681421812074,"score_gpt":0.249074954795317,"score_spread":0.2351981405771963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}