{"id":"W2535017817","doi":"10.1038/ng.3691","title":"Deregulation of DUX4 and ERG in acute lymphoblastic leukemia","year":2016,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":318,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health","keywords":"Erg; Biology; Transactivation; ETS transcription factor family; Transcription factor; Gene isoform; Transcription (linguistics); Cancer research; Molecular biology; Exon; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002469059,0.0002787019,0.000279842,0.0007756053,0.0002230296,0.0005863192,0.0003249971,0.0004967007,0.0031898],"category_scores_gemma":[0.0004881055,0.0001939689,0.0002534621,0.0004309328,0.0003694989,0.000261875,0.0003607969,0.0003333363,0.0004110415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005372083,"about_ca_system_score_gemma":0.0002703464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009899682,"about_ca_topic_score_gemma":0.0009839166,"domain_scores_codex":[0.9997714,0.00007023825,0.00001880224,0.00002909472,0.00005780617,0.00005259102],"domain_scores_gemma":[0.9998117,0.00006048384,0.00005558371,0.00002001987,0.00001530768,0.00003703444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003118307,0.0001570445,0.1016903,0.0002309479,0.0002622617,0.00831534,0.0002280123,0.003243298,0.8330509,0.005573795,0.001583604,0.04254616],"study_design_scores_gemma":[0.0003728832,0.0005277366,0.5132382,0.00009484824,0.0005352967,0.03603167,0.0009385732,0.009636148,0.3969304,0.006733863,0.03489973,0.00006069911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929255,0.00293228,0.0009457511,0.0003748837,0.00003810919,0.000009133375,0.000316306,0.00005240179,0.002405636],"genre_scores_gemma":[0.9968584,0.0008956122,0.0003695366,0.00007504027,0.00001280166,0.000005734209,0.0002540139,0.00001703034,0.00151177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0031898,"threshold_uncertainty_score":0.01067096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008064641672652197,"score_gpt":0.276440814094796,"score_spread":0.2683761724221438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}