{"id":"W2535197426","doi":"10.1182/blood.v106.11.1951.1951","title":"Exposure of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Prothrombinase; Thrombin; Chemistry; Factor X; Factor IXa; Binding site; Cleavage (geology); Biochemistry; Active site; Stereochemistry; Enzyme; Factor V; Platelet; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002447272,0.0004017856,0.0002892502,0.0001823817,0.0001060231,0.0004433311,0.000330342,0.0003361627,0.002415704],"category_scores_gemma":[0.0003899782,0.0002522391,0.0002913178,0.000103186,0.0002168279,0.0002662008,0.0004049282,0.000505294,0.0008577593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003752282,"about_ca_system_score_gemma":0.0002386887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004848191,"about_ca_topic_score_gemma":0.0005516091,"domain_scores_codex":[0.9995195,0.000109792,0.00007376272,0.00009963577,0.0001160104,0.00008125174],"domain_scores_gemma":[0.9993178,0.0001261422,0.0002369741,0.00007835958,0.0000584984,0.000182293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114339,0.00003225927,0.0001718924,0.00001455628,0.000003363296,0.00006037394,0.00000698316,0.00002174457,0.9991892,0.0000402925,0.00003090037,0.0003169486],"study_design_scores_gemma":[0.00003020723,0.0003164597,0.01107838,0.0000093931,0.00001343753,0.0007790797,0.00003590326,0.000753346,0.9829689,0.00004897926,0.003954618,0.00001125768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940514,0.0007216407,0.003159484,0.000101084,0.00006884534,0.00005150911,0.0005900744,0.0001026251,0.00115319],"genre_scores_gemma":[0.9930176,0.0001813964,0.00191387,0.00006166726,0.00001638507,0.00005934975,0.00225039,0.00004660984,0.002452889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002415704,"threshold_uncertainty_score":0.008081377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03603556168223308,"score_gpt":0.2777853166949802,"score_spread":0.2417497550127471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}