{"id":"W2535218491","doi":"10.1038/ijo.2016.183","title":"High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons","year":2016,"lang":"en","type":"article","venue":"International Journal of Obesity","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":225,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Endocrinology; Internal medicine; Neuropeptide Y receptor; Proinflammatory cytokine; Inflammation; Tumor necrosis factor alpha; Hypothalamus; Appetite; Leptin; Medicine; Biology; Neuropeptide; Obesity; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005542442,0.000154177,0.0002449978,0.0002357996,0.00008437274,0.0000795218,0.0003761848,0.0000606012,0.00002873978],"category_scores_gemma":[0.0004660435,0.00008830937,0.0000712098,0.0001181347,0.0001730846,0.0005304621,0.00009760722,0.0001889767,0.000007462711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008086314,"about_ca_system_score_gemma":0.00002285349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002088024,"about_ca_topic_score_gemma":0.00002182136,"domain_scores_codex":[0.9982032,0.0003350084,0.0004585475,0.0002071808,0.0006485502,0.000147492],"domain_scores_gemma":[0.9979432,0.001207751,0.0005491535,0.0001355969,0.0001108004,0.00005347255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007759934,0.0001070872,0.03882493,0.00003616566,0.00005502405,0.0001064236,0.0003727943,0.0003396484,0.9207616,0.006519478,0.00009551844,0.03200535],"study_design_scores_gemma":[0.00155522,0.0008097861,0.3842037,0.0003480585,0.00002079113,0.0000991257,0.000009753496,0.00009053714,0.6103213,0.002332466,0.0001177774,0.00009147343],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962937,0.00003448345,0.0001225537,0.002883656,0.0003752076,0.0001547014,0.00001537433,0.000007806008,0.0001125057],"genre_scores_gemma":[0.9992003,0.0002099836,0.0000732706,0.00008897953,0.0003540259,0.000002377385,0.000001145729,0.000008844034,0.00006104673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3453787,"threshold_uncertainty_score":0.3601152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365376396985648,"score_gpt":0.2587529860283275,"score_spread":0.245099222058471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}