{"id":"W2535345983","doi":"10.1021/acs.chemrestox.6b00203","title":"Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced<i>O</i><sup>6</sup>-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice","year":2016,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Medicinal Plant Extracts Effects","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Carcinogen; Chemistry; Metabolite; Pharmacology; Glucuronidation; Lung cancer; DNA damage; Biochemistry; Internal medicine; Microsome; DNA; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042105,0.0004521175,0.0003258242,0.0005243279,0.0002053287,0.0002150183,0.0003937062,0.0004548227,0.001303908],"category_scores_gemma":[0.0001582899,0.0002715743,0.0004478229,0.0001916503,0.0003951985,0.0002995835,0.0002072322,0.001058912,0.0003983955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758905,"about_ca_system_score_gemma":0.0003113559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001504357,"about_ca_topic_score_gemma":0.002604769,"domain_scores_codex":[0.9996749,0.00004741479,0.00004231364,0.0000741447,0.00007529457,0.00008597426],"domain_scores_gemma":[0.9996568,0.00003587274,0.0001082549,0.00003533141,0.00003513347,0.0001285874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001804286,0.00004843025,0.0001144113,0.00001683063,0.000003786328,0.00002114389,0.000009541412,0.00001992629,0.9992315,0.00002925578,0.00001492628,0.0003098048],"study_design_scores_gemma":[0.00002517312,0.001326922,0.003943344,0.000004763605,0.00002072903,0.0001257002,0.00003854032,0.0002851739,0.9934559,0.00002579034,0.0007438653,0.000003908299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939848,0.001402375,0.002115873,0.0002163109,0.00007939547,0.00006100806,0.0006292831,0.0001835299,0.00132758],"genre_scores_gemma":[0.9909939,0.001350021,0.001875919,0.0001213636,0.00003071068,0.00009394914,0.0007563427,0.00004925079,0.004728506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504357,"threshold_uncertainty_score":0.004362047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05704686046671046,"score_gpt":0.3400758445797255,"score_spread":0.283028984113015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}