{"id":"W2535453502","doi":"10.1016/j.bmc.2016.10.017","title":"Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; American Asthma Foundation; National Science Foundation","keywords":"Chemistry; Arachidonic acid; Affinity chromatography; Lipoxygenase; Hydroxyeicosatetraenoic acid; Enzyme; Biochemistry; Biological activity; Dehydrogenase; Chemotaxis; Chemical synthesis; Biosynthesis; Stereochemistry; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003055943,0.0001277533,0.0001809036,0.00001522818,0.00007203525,0.000002454625,0.0001654648,0.0001873081,0.00001283654],"category_scores_gemma":[0.0003200478,0.00006901411,0.0000790614,0.00008607797,0.0004165231,0.000001837712,0.00004846155,0.0000438781,3.925378e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005218526,"about_ca_system_score_gemma":0.00005952032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003048433,"about_ca_topic_score_gemma":4.298275e-7,"domain_scores_codex":[0.9992824,0.00001367116,0.0002400605,0.0002146444,0.0001100056,0.0001392517],"domain_scores_gemma":[0.9992326,0.0001825955,0.0001718433,0.0002705917,0.00008978307,0.00005260203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000978942,0.00005700072,0.0003834924,0.000133428,0.0001642312,2.760934e-7,0.00003225196,2.187221e-7,0.9968717,0.000007434723,0.0005420396,0.001710054],"study_design_scores_gemma":[0.0005414416,0.0001116037,0.0005957867,0.0000923015,0.0001380161,0.00001665919,0.0001136887,0.00001146198,0.9976551,0.00002734167,0.0006054309,0.00009117289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846615,0.00980734,0.00444193,0.0006817822,0.00005197425,0.0002271933,0.00003255042,0.000009452478,0.00008622971],"genre_scores_gemma":[0.9960456,0.003386454,0.0003451725,0.0000224653,0.00009930341,0.00002588602,0.000005375236,0.00001334656,0.00005637846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01138407,"threshold_uncertainty_score":0.2814314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085190287201076,"score_gpt":0.2233060868265719,"score_spread":0.2124541839545612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}