{"id":"W2535460717","doi":"10.1016/j.bbagen.2016.10.019","title":"The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Wellcome; Innovative Medicines Initiative; Biological and Environmental Research; National Natural Science Foundation of China; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Boehringer Ingelheim; AbbVie; Pfizer","keywords":"Deubiquitinating enzyme; Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Biology; Cell biology; Plasma protein binding; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636772,0.0003723408,0.0005456294,0.000158284,0.0003089304,0.0009554683,0.0003362568,0.0003617288,0.002711145],"category_scores_gemma":[0.0003881786,0.0002428084,0.0002671013,0.0003037088,0.0002747445,0.0006516958,0.0003562,0.001234604,0.001057374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005335489,"about_ca_system_score_gemma":0.0005972055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161653,"about_ca_topic_score_gemma":0.002695184,"domain_scores_codex":[0.9998839,0.00001435873,0.000007378092,0.00001566402,0.00006233473,0.00001628987],"domain_scores_gemma":[0.9998441,0.00003878992,0.00002489672,0.00002413536,0.00003276534,0.00003534167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002790407,0.0003743792,0.01458045,0.0009654308,0.0002716717,0.001362972,0.0008005154,0.005506738,0.749967,0.02923787,0.03953848,0.1546039],"study_design_scores_gemma":[0.0001856884,0.0001966529,0.0171442,0.00003655783,0.000120825,0.002113746,0.0006703886,0.0160577,0.6877487,0.01112823,0.2645048,0.00009242787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9112093,0.0202515,0.03273368,0.003598924,0.001218395,0.00009591895,0.00483904,0.001860976,0.02419216],"genre_scores_gemma":[0.9259725,0.007265628,0.02253021,0.0007463287,0.0001070179,0.00004361803,0.00929328,0.00008495773,0.03395643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002711145,"threshold_uncertainty_score":0.009069681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01540620243123753,"score_gpt":0.2540679511276152,"score_spread":0.2386617486963777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}