{"id":"W2535905227","doi":"10.1002/pd.4944","title":"Current controversies in prenatal diagnosis 2: for those women screened by NIPT using cell free DNA, maternal serum markers are obsolete","year":2016,"lang":"en","type":"article","venue":"Prenatal Diagnosis","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Aneuploidy; Cell-free fetal DNA; Prenatal diagnosis; Medicine; Prenatal screening; Obstetrics; Pregnancy; Gynecology; False positive rate; Adverse effect; Fetus; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004839979,0.000678952,0.0009583263,0.0003523103,0.0001875849,0.0001246944,0.0006799658,0.0003084356,0.0003419899],"category_scores_gemma":[0.003702518,0.0005390854,0.0003470732,0.0003301268,0.0002465231,0.0005442708,0.0006204191,0.0003434782,0.00004466614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007158107,"about_ca_system_score_gemma":0.0001378645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005485869,"about_ca_topic_score_gemma":0.0001463292,"domain_scores_codex":[0.9958086,0.0001485383,0.0008057198,0.001031146,0.0007324197,0.001473601],"domain_scores_gemma":[0.9943429,0.003443232,0.0004178079,0.0008808098,0.000190886,0.0007243907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001840258,0.0009329394,0.9160099,0.001028672,0.0002037218,0.0001397317,0.0002410699,0.00002165973,0.0007888273,0.00003912725,0.03616861,0.0425855],"study_design_scores_gemma":[0.04496007,0.002533598,0.4820124,0.02077601,0.0008655569,0.00007027946,0.0009023277,0.001563536,0.4088865,0.0009888281,0.0336985,0.00274244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776752,0.006470278,0.0009158569,0.001837647,0.0007607014,0.001820915,0.01016452,0.0001815962,0.0001732679],"genre_scores_gemma":[0.992122,0.002961301,0.001340659,0.000500795,0.0003110045,0.002250183,0.0001482575,0.0001243262,0.0002415048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4339975,"threshold_uncertainty_score":0.9997061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0206694119386517,"score_gpt":0.2640645544336743,"score_spread":0.2433951424950226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}