{"id":"W2536022678","doi":"10.1021/acs.jmedchem.6b00895","title":"Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University Health Centre","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; American Asthma Foundation","keywords":"Chemistry; Pharmacokinetics; Pharmacology; Chemotaxis; Eosinophil; Receptor; CYP3A4; Hydroxylation; Metabolism; Antagonist; Biochemistry; Enzyme; Cytochrome P450; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002333689,0.0002622786,0.0004051823,0.000195115,0.0001613895,0.0003585532,0.0001097688,0.0002971519,0.0008934405],"category_scores_gemma":[0.0004847162,0.0002339774,0.0002140059,0.0001497424,0.0002805968,0.0002963823,0.000106553,0.0004659205,0.0003947775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498802,"about_ca_system_score_gemma":0.0002328739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009543138,"about_ca_topic_score_gemma":0.0007815243,"domain_scores_codex":[0.9998693,0.00004805011,0.000007060205,0.00003395155,0.00001862953,0.00002300438],"domain_scores_gemma":[0.9998344,0.00003156845,0.0000587719,0.00002563138,0.00001053994,0.00003913525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02603837,0.0007913242,0.01881135,0.0000844965,0.0001537351,0.0005807633,0.0004265528,0.0007024798,0.9170383,0.0004096641,0.0004977405,0.03446519],"study_design_scores_gemma":[0.001264171,0.07675081,0.214997,0.00003858481,0.0009150237,0.004140197,0.0006045859,0.01185573,0.6686393,0.000813318,0.01990167,0.000079671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997202,0.001453316,0.0005734091,0.00004549511,0.000008292903,0.00002441917,0.0001816934,0.00002095318,0.0004904137],"genre_scores_gemma":[0.9971972,0.0008881048,0.0005476905,0.00006683763,0.0000185332,0.00004669985,0.0003148621,0.00001867325,0.0009014094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009543138,"threshold_uncertainty_score":0.002988875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007867744372131398,"score_gpt":0.2553426339949249,"score_spread":0.2474748896227935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}