{"id":"W2536114505","doi":"10.1182/blood.v124.21.278.278","title":"Improvement in Treatment Outcome and Identification of a New Prognostic Parameter in Down Syndrome Acute Myeloid Leukemia (DS-AML): Results of the Children’s Oncology Group (COG) Phase III AAML0431 Trial","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Medicine; Daunorubicin; Cytarabine; Internal medicine; Minimal residual disease; Oncology; Myeloid leukemia; Absolute neutrophil count; Gastroenterology; Leukemia; Toxicity; Neutropenia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00364954,0.0009802902,0.001161103,0.0002828209,0.0003134954,0.0009547117,0.0007071145,0.001091836,0.001398818],"category_scores_gemma":[0.0019245,0.0002376022,0.00128494,0.0003145075,0.0005494216,0.0006773762,0.0004671136,0.002078983,0.0002337205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007556565,"about_ca_system_score_gemma":0.0008331076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005746947,"about_ca_topic_score_gemma":0.001053785,"domain_scores_codex":[0.9990244,0.0006531286,0.00005424017,0.0001029205,0.00008784884,0.00007744387],"domain_scores_gemma":[0.9980224,0.0006317119,0.0005464422,0.0001455849,0.0001010793,0.0005526811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8607411,0.01004375,0.04879014,0.0005603617,0.002563659,0.0001052189,0.0001163133,0.002585684,0.007924479,0.0002498816,0.003873763,0.06244567],"study_design_scores_gemma":[0.5452421,0.2589835,0.1764535,0.0001643006,0.003887482,0.0004255107,0.00008442279,0.004737605,0.00374986,0.000822701,0.005357491,0.00009160128],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957975,0.001945405,0.0001553567,0.0004570555,0.00007405814,0.000289138,0.0006404556,0.00001925034,0.0006217481],"genre_scores_gemma":[0.9946221,0.000742163,0.0007540341,0.0006800045,0.0001923293,0.0004640158,0.001908562,0.000009254672,0.000627609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00364954,"threshold_uncertainty_score":0.01930082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415389287430947,"score_gpt":0.3225078377355551,"score_spread":0.2983539448612456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}