{"id":"W2536236258","doi":"10.1186/s41181-016-0019-z","title":"Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis","year":2016,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"Université de Genève; Fondation Leenaards","keywords":"In vivo; Biodistribution; Integrin; Chemistry; Peptide; Ex vivo; In vitro; Angiogenesis; Positron emission tomography; Imaging agent; Ligand (biochemistry); Cancer research; Receptor; Medicine; Nuclear medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003155721,0.000201529,0.00043392,0.00007005709,0.00006604042,0.00001485616,0.0001434059,0.00009101772,0.0007309722],"category_scores_gemma":[0.0004798968,0.0001635137,0.0001187436,0.0002137264,0.0002469844,0.00009470717,0.0001328566,0.0001263731,0.00001143726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004635892,"about_ca_system_score_gemma":0.0001285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002170505,"about_ca_topic_score_gemma":5.543814e-7,"domain_scores_codex":[0.998239,0.00005773018,0.0005863608,0.0004540459,0.0003922805,0.0002706107],"domain_scores_gemma":[0.9985096,0.0003191654,0.0001794015,0.0003800005,0.000218379,0.0003934641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005242637,0.0002434639,0.006826849,0.0005490751,0.000110135,0.00001358693,0.0001876296,5.115903e-7,0.9813455,0.000003228203,0.006355076,0.00384073],"study_design_scores_gemma":[0.003492683,0.0001257358,0.002801565,0.000224819,0.0001452386,0.00005822233,0.00007674153,0.00009299482,0.9884825,0.00001956516,0.004311948,0.0001680135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956685,0.001041804,0.0001895872,0.001139319,0.00002320847,0.0004500545,0.0001430382,0.00003340418,0.001311061],"genre_scores_gemma":[0.9934436,0.0008745379,0.001189886,0.0001136358,0.00008222769,0.00004915156,0.00004475112,0.00003244619,0.004169762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007137023,"threshold_uncertainty_score":0.8003633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680651837666735,"score_gpt":0.3270653319920512,"score_spread":0.3102588136153838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}