{"id":"W2536236258","doi":"10.1186/s41181-016-0019-z","title":"Preclinical validations of [18F]FPyPEGCBT-c(RGDfK): a 18F-labelled RGD peptide prepared by ligation of 2-cyanobenzothiazole and 1,2-aminothiol to image angiogenesis","year":2016,"lang":"en","type":"article","venue":"EJNMMI Radiopharmacy and Chemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"Université de Genève; Fondation Leenaards","keywords":"In vivo; Biodistribution; Integrin; Chemistry; Peptide; Ex vivo; In vitro; Angiogenesis; Positron emission tomography; Imaging agent; Ligand (biochemistry); Cancer research; Receptor; Medicine; Nuclear medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004551233,0.0006780489,0.0004369029,0.0002563552,0.0001580433,0.0002773296,0.0004157303,0.0006034175,0.000905963],"category_scores_gemma":[0.0003394533,0.0001997533,0.0002617073,0.0002269488,0.0003207609,0.0001721269,0.0001293855,0.0006631261,0.0003239972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845245,"about_ca_system_score_gemma":0.0004605018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001824522,"about_ca_topic_score_gemma":0.001793649,"domain_scores_codex":[0.9998127,0.0000429743,0.00000943445,0.00003440935,0.00005013287,0.00005033307],"domain_scores_gemma":[0.9997821,0.00004153181,0.00005624991,0.00001923824,0.00005963608,0.00004119666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000591573,0.0004247598,0.0002151488,0.0001319238,0.00001503546,0.00007579671,0.00003513223,0.001120254,0.9942999,0.00005085457,0.0001521111,0.002887437],"study_design_scores_gemma":[0.0001085581,0.01341909,0.002242567,0.00001213239,0.00008005751,0.0004731456,0.00002938757,0.0019577,0.9779775,0.00002683169,0.003659891,0.00001317098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98974,0.002832012,0.004963815,0.00009760666,0.00004297912,0.000343236,0.0006235407,0.0000897977,0.001267097],"genre_scores_gemma":[0.9906888,0.002031835,0.004501735,0.00007353837,0.00001980848,0.0002492777,0.000755691,0.00003544598,0.001643799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824522,"threshold_uncertainty_score":0.003627777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01680651837666735,"score_gpt":0.3270653319920512,"score_spread":0.3102588136153838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}